Water plays a vital role in adapting natural and human systems in a climate change scenario. Understandinghow this fundamental element of life is organized and functioning is essentialtogather, disseminate, and advanceknowledge about water at the micro and nanostructure level. With developments in the different research areas, the International Panel on Water Structure–IPWS was created during the 8thWorld Water Forum(WWF)inBrasília,2018,to connect researchersspecialized inwater structure under aninterdisciplinary perspective.In 2020 a partnership between CIRAT –International Center on Water and Transdisciplinarityand WATER–a Multidisciplinary Research Journalhasbegun, intendedto organize a special edition on Water and Transdisciplinarityto be launched during the 9thWWF, in Dakar, on March 24th, 2022, in response to the challenges of our century, with the aim to disclose advanced knowledge about water at different structural levels, leading to a new understanding of it.The whole project was organized by Prof. Leoni Bonamin, from UniversityPaulista, with the support of the Editor-in-Chief Prof. Gerald Pollack, from Washington University at Seattle. The focus was on the cross-over of information with technical quality and bold thinking, as shown in Figure 1 below.Homeopathy wasincludedamong the themes.Aftera multi-step process, in which manuscripts were received (after personal invitationssent to more than 200 researchers in the field)andevaluated in a two-step peer review processto ensure maximum scientific understanding, the result showed a set of innovative contributions in which authors were allowed to be bold in their projects while careful with the methodology. Theentire process was carried out voluntarily by all the actors involved.Thus, the whole editorial process was philanthropic, there were no costs for the authors, and all articles were published as open access.

Authors from five countries participated in this project:

Brazil, India, Italy, Russia, and the United States.

Different sessions were organized according to the topics:

"Opinion Article," "Hypotheses," "Water Structure," "High Dilutions," "Water and Environment," and "New Devices."Fiveof twelve articles reported results on high dilutions, including its physicochemical propertiesandthe implications on biological systems, such as plants and aquatic animals [1-4]. This initiative inspired all to envision the possibility of offering practical solutions to old problems involving different ways of water management, which couldreduce social gaps and improve the quality of life fairly and universally.