Valor predictivo de la hiperbilirrubinemia en perforación apendicular
Predictive value of hyperbilirubinemia in appendicular Perforation

Rev. venez. cir; 67 (3), 2014
Publication year: 2014

Recientemente, se ha propuesto a la bilirrubina total como un marcador específico de perforación apendicular así como la PCR y los glóbulos bláncos.

Objetivo:

Determinar el valor diagnóstico de la hiperbilirrubinemia como predictor de perforación apendicular.

Métodos:

un estudio prospectivo en pacientes con diagnóstico de apendicitis aguda en el Hospital “Dr. Manuel Núñez Tovar”, evaluándose características preoperatorias, incluyendo tiempo de evolución preoperatoria, cuenta blanca y bilirrubina total.

Resultados:

De 153 pacientes estudiados, hubo predominio del sexo femenino 78 (50,98%) entre 12 y 30 años (64%). La media de horas de clínica preoperatoria, glóbulos blancos y la bilirrubina total fueron más altas en las fases avanzadas con 33,93 horas ± 16, 17.666 cel/mm3 y 1,4 mg/dl respectivamente, en la fase perforada. La especificidad de la bilirrubina para perforación apendicular fue alta (75%) comparado con la observada en la cuenta blanca (48%) e incluso una aceptable sensibilidad. Lo mismo fue cierto para el valor predictivo positivo de la bilirrubina para la perforación apendicular (71%) comparado con los leucocitos (52%).

Conclusión:

Los pacientes con hiperbilirrubinemia y síntomas clínicos de apendicitis aguda, demuestran tener una probabilidad más alta de perforación apendicular que aquellos con niveles regulares de bilirrubina(AU)
Recently, it has been proposed to total bilirubin (BT) as a specific marker for ruptured appendix and the CRP and white blood cells.

Objective:

To determine the diagnostic value of hyperbilirubinemia as a predictor of appendiceal perforation in patients with a diagnosis of acute appendicitis.

Methods:

A prospective study in patients undergoing surgery with a diagnosis of acute appendicitis in the emergency service of the Hospital "Dr. Manuel Nuñez Tovar", evaluating the preoperative characteristics of patients in each group according to anatomical-clinical findings, including the time of preoperative clinical, white count and total bilirubin.

Results:

Of 153 patients studied, 64 had clinical anatomical findings gangrenous and perforated appendix (incidence 41.83%). It was a female predominance with 78 (50.98%) patients. Most patients were aged between 12 and 30 with 97 (64%). The mean preoperative clinical hours, the white blood cells and total bilirubin were higher in advanced stages with 33.93 hours ± 16, 17,666 cells/mm3 and 1.4 mg / dl respectively, in the perforated stage. The specificity of appendiceal perforation bilirubin was high (75%) compared with that observed in white blood cells (48%) and even an acceptable sensitivity. The same was true for the positive predictive value of bilirubin for appendiceal perforation (71%) compared with leukocytes (52%).

Conclusion:

Patients with hyperbilirubinemia and symptoms of acute appendicitis, demonstrate a higher probability of appendiceal perforation than those with regular levels of bilirubin(AU)

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