The purpose of this study was to evaluate the effect of cholestyramine and lovastatin, lipid-lowering agents, upon egg quality, reproductive performance, plasma lipids and egg yolk cholesterol levels of Shaver laying hens. Twenty-six-weeks-old hens were fed basal diet without animal products containing 0.2 per cent cholestyramine (COL1), 0.3 per cent cholestyramine (COL2) or 0.005 per cent lovastatin (LOV) for 6 weeks. If was observed that the supplementation of the significant reduction (p<0.05) in egg weights. No significant changes were observed on plasma lipids, and egg yolk cholesterol remained unchanged with the addition of the drugs