During the last decades, there has been a significant growth in ambulatory surgeries. Literature, unfortunately, tells us that more than 75% of children have pain during the postoperative period, when they have been discharged, and 40% of these children have mild to severe pain. Caregivers turn to the surgeon, pediatrician or the clinic, places where usually there is no pain management specialist. Frequently, even when pain is evident, children get inadequate treatment. It is inadequate to say that children don’t remember or don’t respond to a painful experience at the same level as adults do. Many of the transmission and perception nerve tracts are developed in early life, being present and in function since week 24 of intrauterine gestation. The mistreated pain has immediate and long-term consequences. For clinicians, it is of utmost importance the knowledge of these consequences, summarizing, lifestyle deterioration, extended usage of (analgesics) painkillers and onset of persistent or chronic pain. Toddlers are not able to describe their pain or their subjective experience, due to this, the caregiver must learn how to eva- luate properly. This evaluation is intended for every pediatric patient who meets the criteria for an ambulatory surgery. The main objective is to highlight the importance of a safe and effective analgesic management. The most appropriate method to treat postoperative severe pain is multimodal, which involves nonpharmacological, pharmacological, and local anesthetic techniques. The patients’ selection, the early anesthetic strategy planning and caregivers’ education are the keys for success.