Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats
Acta cir. bras; 31 (5), 2016
Publication year: 2016
ABSTRACT PURPOSE :
To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use.METHODS:
Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9.RESULTS:
Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods.CONCLUSION:
The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.
Antiinflamatorios no Esteroideos/farmacología, Inhibidores de la Ciclooxigenasa/farmacología, Íleon/cirugía, Tiazinas/farmacología, Tiazoles/farmacología, Cicatrización de Heridas/efectos de los fármacos, Anastomosis Quirúrgica, Colágeno Tipo I/metabolismo, Colágeno Tipo III/metabolismo, Íleon/irrigación sanguínea, Metaloproteinasa 9 de la Matriz/efectos de los fármacos, Metaloproteinasa 9 de la Matriz/metabolismo, Modelos Animales, Neovascularización Fisiológica/efectos de los fármacos, Periodo Posoperatorio, Distribución Aleatoria, Ratas Wistar, Receptores de Factores de Crecimiento Endotelial Vascular/efectos de los fármacos, Receptores de Factores de Crecimiento Endotelial Vascular/metabolismo, Factores de Tiempo