Estudio de asociación del polimorfismo -866 G/A del gen UCP2 con obesidad en una población de Valledupar
Association Study of the -866 G/A UCP2 Gene Polymorphism with Obesity in a Valledupar Population
Estudo de associação do polimorfismo -866G/A do gene UCP2 com obesidade em uma população de Valledupar
Rev. cienc. salud (Bogotá); 12 (2), 2014
Publication year: 2014
La obesidad es una enfermedad multifactorial que se relaciona con estilos de vida y factores medioambientales y genéticos. Uno de los genes candidatos de la obesidad es el UCP2. Su polimorfismo -866G/A se ha asociado con obesidad en algunas poblaciones. Sin embargo, se han reportado resultados contradictorios alrededor del mundo, lo cual indica la necesidad de nuevas investigaciones al respecto.
Objetivo:
Analizar el polimorfismo -866G/A del gen UCP2 asociado con obesidad en adultos de la ciudad de Valledupar.Materiales y métodos:
Se estudiaron 103 individuos con sobrepeso u obesidad y 100 con normopeso. El polimorfismo de UCP2 -866G/A fue determinado por PCR-RFLP. Se evaluaron también medidas antropométricas, perfil de lipoproteÃnas y glucemia basal.Resultados:
Se observó que el alelo mutado y su genotipo homocigoto fueron significativamente más frecuentes en pacientes con IMC > a 25 kg/m². [A: OR= 2,9 (IC 95%= 1,765-4,751) y AA: OR=5,8 (IC 95%= 1,264-2,745)]. No se encontraron diferencias significativas entre UCP2 -866G/A y las variables clÃnicas estudiadas en individuos obesos. Sin embargo, se observa que los sujetos con alelos y genotipos mutados presentaron cifras más elevadas de triglicéridos, glucemia e ICC y menor promedio de cHDL.Conclusiones:
la mutación -866G/A del gen UCP2 se asocia a obesidad en la población estudiada y aunque no parece influir en las medidas antropométricas y bioquÃmicas en sujetos obesos, podrÃa estar relacionado con aumento de ICC, glucosa y triglicéridos y disminución de cHDL.
Obesity is a multifactorial disease that is related to lifestyles, and environmental and genetic factors. One of the candidate genes for obesity is the UCP2. Its polymorphism -866G/A was associated with obesity in some populations. However, conflicting results have been reported around the world, indicating the need for further investigations.
Objective:
To analyze the polymorphism -866G/A UCP2 gene associated with obesity in adults in the city of Valledupar.Materials and methods:
We studied 103 overweight or obese individuals and 100 normal weight. The polymorphism of UCP2 -866G/A was determined by PCR-RFLP. Anthropometric measures were also evaluated, lipoprotein profile and fasting glucose.Results:
We found that the mutated allele and homozygous genotype were significantly more frequent in patients with BMI > 25 kg/m². [A: OR = 2.9 (95% CI= 1,765 to 4,751 ) and AA: OR= 5.8 (95% CI = 1,264 to 2,745)]. No significant differences were found between UCP2 -866G/A and the clinical variables studied in obese individuals. However it is observed that subjects with mutated alleles and genotypes had higher triglycerides, glucose and ICC and lower average HDL cholesterol.Conclusions:
mutation -866G/A UCP2 gene is associated with obesity in the population studied, and although it seems to influence the anthropometric and biochemical measures in obese subjects could be related to increased ICC, glucose and triglycerides and decreased HDL.
A obesidade é uma doença multifatorial que se relaciona com estilos de vida, e fatores meio ambientais e genéticos. Um dos genes candidatos da obesidade é o UCP2. Seu polimorfismo -866G/A tem se associado com obesidade em algumas populações. No entanto, tem se reportado resultados contraditórios ao redor do mundo, o qual indica a necessidade de novas pesquisas a respeito.