With this paper I intend to join to theorists who have discussed issues of difference and identity, with the aim of problematising some of the knowing/doing dimensions of nursing in contemporaneity. I am using as an analytical-theoretical background the Cultural Studies and Gender theories that develop a critical approach to post-structuralism. In the light of such a background I analyse some elements or constitutive aspects of the current theories on Care. I argue that to think care from the perspective of difference is to accept the challenge of not thinking about it as an action underpinned by scientific, philosophical and universal humanitarian assumptions, and start its theorisation and exercise as an action that is fundamentally political.