As of March 2016, Humberto Reyes, MD, FACP, steps down as Editor-in-Chief of Revista Médica de Chile. He joined its editorial team in 1971, as a part-time Assistant Editor. A few years later he became Associate Editor and since 1996, Editor-in-Chief. During his tenure the journal improved the peer review system and implemented a web platform to handle the editorial process, while following the recommendations established by acknowledged organizations such as the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Journal Editors (WAME) and the Committee on Publication Ethics (COPE). Since 2010 he represented Revista Médica de Chile as an ICMJE Member. After an open contest, the Sociedad Médica de Santiago, founder and owner of Revista Médica de Chile since 1872, elected Fernando Florenzano MD as the new Editor-in-Chief. Dr. Reyes leaves this long lasting job with the satisfaction of having conducted an institution considered among mainstream medical journals in spite of being mostly published in Spanish. Revista Médica de Chile receives a high proportion of the research articles that have been generated in the country, subsequently handled by an enthusiastic and solid editorial team whose responsibilities go far beyond selecting the material to be published since they are medical educators striving to help authors to improve their papers before having them published. Conducting this journal has been a fascinating task for this Editor as well as an unforgettable experience.