Terapêutica empírica com amiodarona em portadores de miocardiopatia chagásica crônica e taquicardia ventricular sustentada
Long term results of empiric amiodarone therapy in patients with sustained ventricular tachycardia and chronic chagasic myocarditis
Arq. bras. cardiol; 54 (6), 1990
Publication year: 1990
Objetivo:
Avaliar eficácia e tolerância do uso empírico de amiodarona, a longo prazo, em portadores d e Miocardiopatia Chagásica Crônica (MCC) e Taquicardia Ventricular Sustentada (TVS).Casuística e Métodos:
Trinta e cinco portadores de MCC e TVS, 18 (51% ) dos quais, refratários a outras drogas antiarritmicas. A dose de impregnação variou de 600 a 1200 (média de 883 ± 239) mg/dia, por período de uma a quatro semanas. A dose de manutenção foi reduzida progressivamente à média de 356 ± 125 mg/dia ao final de seis a 80 (média de 27 ± 20) meses. Foram construídas curvas de estimativa de recorrência clínica, morte súbida e morte cardíaca, segundo o método de Kaplan e Meier e comparadas variáveis clínicas na avaliação de risco de recorrências e morte súbita, através dos testes do Qui-quadrado de Pearson e t de Student.Purpose:
To evaluate the efficacy and safety of long-term empiric amiodarone therapy in patients with recurrent Sustained Ventricular Tachycardia (SVT) and Chronic Chagasic Myocarditis (CCM).Patiens and Methods:
Thirty-five patients with CCM and SVT, eighteen (51%) of them were refratary to other antiarrhythmic drugs. The Amiodarone loading dose was between 600 and 1200 mg/day, mean of 883 ± 239 mg/day, from a period of one to four weeks. The maintenance dose was decreasing in the follow-up period, it fell down to 356 ± 125 mg/day at the end of six to 80 (mean = 27 ± 20) months. Cumulative, event-free interval curves were generated by the Kaplan-Meier method. Clinicals variables were compared with the use of the Student t-test or by means of chi-square tests.
Taquicardia/tratamiento farmacológico, Amiodarona/uso terapéutico, Amiodarona/administración & dosificación, Recurrencia, Estudios de Seguimiento, Cardiomiopatía Chagásica/complicaciones, Cardiomiopatía Chagásica/mortalidad, Taquicardia/etiología, Recurrencia, Tolerancia a Medicamentos, Enfermedad Crónica, Frecuencia Cardíaca/efectos de los fármacos, Probabilidad