Diferentes terapias no tratamento da obesidade em pacientes hipertensos
Different therapies in the treatment of obesity in hypertensive patients
Arq. bras. cardiol; 66 (6), 1996
Publication year: 1996
PURPOSE:
To evaluate the efficacy and tolerability of different therapies associated with diet in the treatment of hypertensive obese patients.METHODS:
In a clinical study we randomly evaluated 39 hypertensive obese patients (body mass index (BMI) > or = 30 kg/m2).After 45 days of diet the patients were again randomly distributed in 3 groups and received in double blind way:
group 1-hypocaloric diet+placebo; group 2-hypocaloric diet+dexfenfluramine; group 3-hypocaloric diet+spiruline+fucus+gelatin. We followed their progress during 12 weeks under medication and further 24 weeks without.We evaluated the groups comparing:
weight, BMI, blood pressure and side-effects.RESULTS:
Twenty seven patients completed the observation. In those patients from groups 1 and 3 no changes in any of parameters were observed. In group 2 we observed a clear loss of weight (-3.8 Kg) and a fall in BMI. Blood Pressure changes were only observed in group 2 (-9.6). The only patients to maintain weight loss after the termination of use of medicines were those from group 2. We did not observe any side-effects.CONCLUSION:
In hypertensive obese patients, when isolated diet is not enough to control weight loss, dexfenfluramine could be useful in association with a controlled diet. The drug assists in weight loss, does not promote side-effects and does not interfere in the treatment of blood pressure.
Objetivo - Avaliar a eficácia e tolerabilidade de diferentes medicamentos, associados à dieta, no controle de hipertensos obesos. Métodos - Estudo clínico randomizado, avaliando 39 pacientes obesos (índice de massa corpórea (IMC)>30kg/ m2 ) que, após 45 dias de dieta, foram aleatoriamente distribuídos em grupos e recebendo, de forma duplo cega:
grupo 1 - dieta hipocalórica + placebo; grupo 2 - dieta hipocalórica + dexfenfluramina (30mg/dia); grupo 3 - dieta hipocalórica + spirulina/fucus/gelatina, tendo sido. seguidos por 12 semanas, usando medicação, e mais 24 semanas, após interrupção da mesma.