Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer
Braz. j. med. biol. res; 50 (6), 2017
Publication year: 2017
Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.
Biomarcadores de Tumor/metabolismo, Expresión Génica/genética, Inhibidores de la Metaloproteinasa de la Matriz/metabolismo, Metaloproteinasas de la Matriz/genética, Metaloproteinasas de la Matriz/metabolismo, Neoplasias Ováricas/enzimología, Neoplasias Ováricas/genética, Neoplasias Ováricas/secundario, Inhibidores Tisulares de Metaloproteinasas/metabolismo