Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults
Clinics; 71 (12), 2016
Publication year: 2016
OBJECTIVES:
The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events.METHODS:
Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA).RESULTS:
Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context.CONCLUSION:
Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.
Factores de Edad, Análisis de Varianza, Antropometría, Biomarcadores/sangre, Proteína C-Reactiva/análisis, Enfermedad de la Arteria Coronaria/sangre, Enfermedad de la Arteria Coronaria/genética, Estudios Transversales, Ingestión de Energía, Ensayo de Inmunoadsorción Enzimática, Técnicas de Genotipaje, Glucuronidasa/sangre, Glucuronidasa/genética, Haplotipos, Homocisteína/sangre, Infarto del Miocardio/sangre, Infarto del Miocardio/genética, Evaluación Nutricional, Valores de Referencia, Factores de Riesgo, Factores Sexuales, Estadísticas no Paramétricas, Accidente Cerebrovascular/sangre, Accidente Cerebrovascular/genética