Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x]
Braz. j. med. biol. res; 51 (1), 2018
Publication year: 2018
A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined.
Antineoplásicos/química, Antineoplásicos/farmacología, Neoplasias de la Mama/tratamiento farmacológico, Línea Celular Tumoral, Complejos de Coordinación/química, Complejos de Coordinación/farmacología, Cristalografía por Rayos X, Formazáns, Estructuras Metalorgánicas/química, Estructuras Metalorgánicas/farmacología, Porfirinas/química, Valores de Referencia, Reproducibilidad de los Resultados, Sales de Tetrazolio