Abstract This exploration of the shift from a psychological understanding of the self to a somatic/cerebral one centers on the duality between the Enlightened, rationalist worldview and the so-called Romantic worldview, characteristic of modern Western culture. The discussion seeks to show how physicalism draws support from a reframing of what L.F. Duarte has called a "relentless tension" between these two worldviews. It finds basis in examples where biotechnological interventions are linked to heavy affective, emotional investment in bodily experiences and puts forward the notion of a contemporary "vitalism," where the category "life" is understood as something that, while anchored in biological materialism, moves beyond it, meshing with fluid categories like happiness and well-being or with feelings and emotions that resist objective definition.