Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex
Acta cir. bras; 33 (6), 2018
Publication year: 2018
Abstract Purpose:
To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress.Methods:
Adult and aged Wistar rats were supplemented with murici extract (150 mg/kg/day or 300 mg/kg/day) by gavage for fifteen days. Afterwards, the animals were submitted to a CSD electrophysiological recording and to brain oxidative stress evaluation.Results:
Our results showed that aging decreased CSD propagation velocity, catalase activity and glutathione/oxidized glutathione ratio (GSH/GSSG) in the brain cortex of the rats, and increased malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activity. The highest dose (300 mg/kg/day) of murici extract accelerated CSD, whereas the lowest (150mg/kg/day) decelerated, in both adult and aged animals. In contrast, aged animals supplemented with murici extract in both doses presented low MDA levels and high GSG/GSSG ratio in comparison to the control-aged animals.Conclusion:
Murici extract supplementation seems to revert detrimental effects in aged brains and could be considered as a strategy in the treatment of pathologies related to aging and cortical spreading depression.
Factores de Edad, Envejecimiento/fisiología, Antioxidantes/farmacología, Catalasa/análisis, Corteza Cerebral/efectos de los fármacos, Corteza Cerebral/metabolismo, Depresión de Propagación Cortical/efectos de los fármacos, Depresión de Propagación Cortical/fisiología, Suplementos Dietéticos, Glutatión/análisis, Disulfuro de Glutatión/análisis, Peroxidación de Lípido, Malondialdehído/análisis, Malpighiaceae/química, Estrés Oxidativo/efectos de los fármacos, Estrés Oxidativo/fisiología, Ratas Wistar, Valores de Referencia, Reproducibilidad de los Resultados, Superóxido Dismutasa/análisis