Rev. colomb. gastroenterol; 31 (4), 2016
Publication year: 2016
Introducción:
la gastritis crónica atrófica (GCA) es una entidad clinicopatológica relacionada con cáncer gástrico (CG) de tipo intestinal. Su principal causa es Helicobacter pylori. Actualmente, además del diagnóstico, se recomienda evaluar la extensión de la atrofia o de la metaplasia intestinal, para estadificar el riesgo de CG. El método más preciso para la atrofia es el OLGA, que exige 5 biopsias: 2 del cuerpo, 2 del antro y 1 de la incisura angularis, marcadas y enviadas en frascos separados. En Colombia, no se ha evaluado el rendimiento de OLGA en el estudio de la atrofia gástrica. Materiales y métodos:
estudio de casos y controles. Los casos son pacientes en quienes se hizo el muestreo de biopsias para el OLGA. Los controles pacientes con menos de 5 biopsias gástricas, sin el muestreo del OLGA. Resultados:
1599 casos y 4191 controles. Edad promedio de los casos:
49±12 años versus controles 54±10 años (p: NS). H. pylori:
60% versus 57%. GCA en casos:
42% versus 26%. El 12,3% tenía OLGA III/IV y el 88%, OLGA 0, I o II, los cuales no ameritarían vigilancia endoscópica. Conclusión:
el sistema OLGA permite detectar un 61,8% más de atrofia que la detectada con un muestreo insuficiente de biopsias gástricas. La mayoría de los casos (88%) tuvo bajo riesgo de CG (estado 0-II) y no se justificaría vigilancia endoscópica.
Introduction:
Chronic atrophic gastritis (GCA) is a clinicopathological entity related to intestinal type gastric cancer (GC) whose main cause is helicobacter pylori. Currently, in addition to the diagnosis, it is recommended that the extent of atrophy or intestinal metaplasia be evaluated in order to stage the GC risk. The most accurate method for atrophy is OLGA which requires five biopsies:
two from the corpus, two from the antrum and one from the angular incisure. Each biopsy is marked placed in a separate tube and marked. In Colombia, the use of OLGA to study gastric atrophy had not been evaluated previously. Materials and methods:
This is a case and control study whose cases are patients who had biopsies taken to be studied with OLGA. Control patients had less than five gastric biopsies, without OLGA sampling. Results:
This study includes 1,599 cases and 4,191 controls. The average age of cases was 49 +/- 12 years, and the average age of controls was 54 +/- 10 years (p: NS). H. pylori infections were found in 60% of the cases and in 57% of the controls while 42% of the cases were found to have gastric cancer and 26% of the cases were found to have GC. 12.3% had OLGA III or IV and 88% had OLGA 0, I or II and did not merit endoscopic monitoring. Conclusion:
The OLGA system detects 61.8% more atrophy than is detected with less sampling of gastric biopsies. Most of the cases (88%) had low risk of GC (stages 0-II) and did not require endoscopic monitoring