Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults
Rev. méd. Chile; 146 (6), 2018
Publication year: 2018
Background:
Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity.Aim:
To investigate the association of FTO gene with adiposity markers in Chilean adults.Material and Methods:
409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses.Adiposity markers included were:
body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio.Results:
A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score.Conclusions:
This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.
Adiposidad/genética, Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética, Genotipo, Obesidad/genética, Adiposidad/etnología, Alelos, Antropometría, Chile/etnología, Estudios Transversales, Marcadores Genéticos, Predisposición Genética a la Enfermedad, Estilo de Vida, Modelos Lineales, Obesidad/etnología, Reacción en Cadena de la Polimerasa, Polimorfismo de Nucleótido Simple, Valores de Referencia, Factores de Riesgo, Factores Socioeconómicos