Impact of 68GA-PSMA PET / CT on treatment of patients with recurrent / metastatic high risk prostate cancer - a multicenter study
Int. braz. j. urol; 44 (5), 2018
Publication year: 2018
ABSTRACT Purpose:
The purpose of our study was to evaluate the clinical impact of 68Ga-PSMA PET / CT in the setting of biochemical recurrence of prostate cancer.Materials and Methods:
We retrospectively evaluated 125 prostate cancer patients submitted to the 68Ga-PSMA PET / CT due to biochemical recurrence. The parameters age, Gleason score, PSA levels, and the highest SUVmax were correlated to potential treatment changes. The highest SUVmax values were correlated with age and Gleason score. The median follow-up time was 24 months.Results:
68Ga-PSMA PET / CT led to a treatment change in 66 / 104 (63.4%) patients (twenty-one patients were lost to follow-up). There was a significant change of treatment plan in patients with a higher Gleason score (P = 0.0233), higher SUVmax (p = 0.0306) and higher PSA levels (P < 0.0001; median PSA = 2.55 ng / mL).Conclusion:
68Ga-PSMA PET / CT in prostate cancer patients with biochemical recurrence has a high impact in patient management.
Ácido Edético/análogos & derivados, Estudios de Seguimiento, Persona de Mediana Edad, Clasificación del Tumor, Recurrencia Local de Neoplasia/diagnóstico por imagen, Recurrencia Local de Neoplasia/terapia, Oligopéptidos, Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos, Antígeno Prostático Específico/sangre, Neoplasias de la Próstata/sangre, Neoplasias de la Próstata/diagnóstico por imagen, Neoplasias de la Próstata/terapia, Estudios Retrospectivos, Sensibilidad y Especificidad