Brain metastases represent a critical stage of oncological disease and its frequency is increasing over the recent years.

The treatment of brain metastases has moved from a conservative approach to an active management that should be individualized for each patient:

in case of single brain metastasis, surgery or radiosurgery should be considered as first option of treatment; in case of multiple lesions, whole-brain radiotherapy is the standard of care. The aim of this review is to present general aspects including new approaches in management of patients with brain metastases.(AU)