Introduction Orofacial Cleft, in particular cleft lip and palate (LPF) constitute a problem of oral health due to its implications and impact in several aspects; Little has been studied of how much socioeconomic factors determine this pathology, such as: the place of housing, whether rural or urban, the age and educational level of the mother and socioeconomic. The objective was to determine the association between age and educational level of the mother at the time of delivery, the area of residence, access to folic acid consumption and socioeconomic level (social determinants) with the risk of having a child with cleft lip and palate in the city of Cuenca. Methodology. An observational, analytical, retrospective study of 138 cases (patients with cleft lip and palate) of hospitals Vicente Corral Moscoso and José Carrasco Arteaga and 162 controls of the same hospitals; Results. The association between socioeconomic level and LPF diagnosis shows an OR = 5,077 (CI 3,098-8,320) p <0.01. The association between the age of the mother and the diagnosis of LPF shows an OR = 1,782 (CI 1,090-2,911) for age at risk (adolescent mother and aged mother) p <0.021 and the association between the mother's educational level and the LPF diagnosis showed an OR = 6,106 (CI 3,690-10,105) p <0.000. The association between folic acid consumption by the mother and the diagnosis of LPF OR = 2,791 (IC 1.687-4.167) p <0.000 Conclusions. There is an interaction between the studied variables (place of residence, mother's level of education, folic acid consumption in pregnancy and socioeconomic level) that determine a higher probability of having a child with LPF.