The document highlights the achievements made in the public health system in Guyana as well as the challenges faced during the past fifty years. It provides an analysis of the country context, the health systems and services, the epidemiological profile, the achievements and challenges, and the health targets for the next fifty years. The Epidemiological profile addresses diseases surveillance and disease profile, including measles, malaria, tuberculosis, HIV/AIDS, dengue, cardiovascular, hypertension, diabetes and cancer.