This report represents a compilation of 2016 statistics based on 52 weeks of epidemiologic surveillance of the Zika virus disease by the EPI Unit, Ministry of Health, Belize. Four tables with corresponding graphs provide a breakdown of the confirmed, suspected (clinical), and suspected (by test)) cases of zika according to epidemiological week, community within the Belize district, age group and sex. The incidence of Zika virus disease was presented for each of the 24 communities that comprise the Belize district as well as for one unknown location within that district. The grand total of Zika virus cases in Belize for 2016 was 349.