Djimde, Moussa;
Tshiongo, Japhet Kabalu;
Muhindo, Hypolite Mavoko;
Tinto, Halidou;
Sevene, Esperança;
Traore, aminata;
Vala, Anifa;
Macuacua, Salesio;
Kabore, Berenger;
Dabira, Edgard Diniba;
Erhart, Annette;
Diakite, Hamadoun;
Keita, Mohamed;
Piqueras, Mireia;
González, Raquel;
Menendez, clara;
Dorlo, Thomas Pc;
Sagara, Issaka;
Mens, Petra;
Schallig, Henk;
D'Alessandro, Umberto;
Kayentao, Kassoum.
Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquin...
Malaria, Falciparum/therapy,
Artemisinins/radiation effects,
Artemether, Lumefantrine Drug Combination,
Randomized Controlled Trials as Topic,
Pregnant Women,
Infection Control,
Parasitology,
Sub-Saharan African People,
Artemether/therapeutic use,
Antimalarials/radiation effects,
Mozambique/epidemiology
Silva , Clemente;
Boene, Simone;
Datta , Debayan;
Valbona, Eduard Rovira;
Díaz, Andrés Aranda 3 4;
Cisteró, Pau;
Hathaway , Nicholas;
Tessema, Sofonias;
Chidimatembue, Arlindo;
Matambisso, Glória;
Nhama, Abel;
Macete, Eusebio;
Pujol, Arnau;
Nhamussua , Lidia;
Galatas, Beatriz;
Guinovart, Caterina;
Enosse, Sónia;
Carvalho, Eva;
Rogier, Eric;
Plucinski, ateusz M;
Colborn, James;
Zulliger, Rose;
Saifodine, Abuchahama;
Alonso, Pedro L;
Candrinho , Baltazar;
Greenhouse , Bryan 3;
Saute, Francisco;
Mayor, Alfredo.
Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite genetic structure in that country. We performed P. falciparum amplicon and whole genome sequencing on 2251 malaria-infected blood samples collected in 2015 a...
Cuinhane, Carlos Eduardo;
Galatas, Beatriz;
Lopez, Julia Montaña;
Djive, Helder;
Nhantumbo, Hoticha;
Murato, Ilda;
Saúte, Francisco;
Aide, Pedro;
Munguambe, Khátia;
Torres, Neusa.
This study analysed acceptability and perceived barriers to reactive focal mass drug administration (rfMDA) among community members exposed to community engagement campaigns and malaria elimination interventions in Magude district, following mass drug administration (MDA) in the same district. The study ...
González, raquel;
Nhampossa, tacilta 3;
Ngoma, ghyslain mombo;
Mischlinger, johannes;
Esen, meral;
Tchouatieu, andré marie;
Duran, clara pons;
Dimessa, lia betty;
Lell, bertrand;
Lagler, heimo;
Otero, laura garcia.
Introduction: Malaria infection during pregnancy is an important driver of maternal and neonatal health especially among HIV-infected women. Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine is recommended for malaria prevention in HIV-uninfected women, but it is contr...
Antimalarials/adverse effects,
Artemisinins,
Artesunate/administration & dosage,
HIV Infections/prevention & control,
Infectious Disease Transmission, Vertical/prevention & control,
Malaria/prevention & control,
Mozambique/epidemiology,
Pregnancy Complications, Parasitic/chemically induced,
Pregnancy Complications, Parasitic/prevention & control,
Quinolines
Nhama , Abel;
Nhamússua, Lídia;
Macete, Eusébio;
Bassat, Quique;
Salvador, Crizolgo;
Enosse, Sónia;
Candrinho, Baltazar;
Carvalho, Eva;
Nhacolo, Arsénio;
Chidimatembue, Arlindo;
Saifodine , Abuchahama;
Zulliger, Rose;
Lucchi, Naomi;
Svigel, Samaly S;
Moriarty , Leah F;
Halsey, Eric S;
Mayor, Alfredo;
Aide , Pedro.
Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy...
Amodiaquine,
Antimalarials/therapeutic use,
Drug Combinations,
Antimalarials/standards,
Parasitemia,
Treatment Outcome,
d0082880,
Artemether, Lumefantrine Drug Combination/pharmacology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Malaria, Falciparum/therapy,
Parasitemia/drug therapy,
Mozambique/epidemiology
Smith, Alexandra Wharton;
Baker, Kevin;
Feltrer, Arantxa Roca;
Rodrigues, Maria;
Richardson, Sol;
Bonnington, Craig A;
Rassi, Christian;
Marasciulo, Madeleine;
Enosse, Sonia;
Saute, Francisco;
Aide, Pedro;
Macete, Eusebio;
Candrinho, Baltazar.
Background
Malaria is a significant cause of morbidity and mortality in children aged under 5 years in Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration of four monthly courses of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ), to childre...
Mayor, Alfredo;
Silva, Clemente;
Valbona, Eduard Rovira;
Feltrer, Arantxa Roca;
Bonnington, Craig;
Smith, Alexandra Wharton;
Greehouse, Bryan;
Bever, Caitlin;
Chidimatembue, Arlindo;
Guinovart, Caterina;
Proctor, Joshua L;
Rodrigues, Maria;
Canana, Neide;
Arnaldo, Paulo;
Boene, Simone;
Enosse, Sonia;
Saute, Francisco;
Candrinho, Baltazar.
Introduction: Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions to reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims to operationalise a functional malaria molecular surveillance system in Moz...
Background: Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaq...
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Drug Resistance/genetics,
Drug Therapy, Combination,
Genetic Markers,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/genetics,
Plasmodium falciparum/isolation & purification,
Polymorphism, Genetic/genetics,
Mozambique
Galatas, beatriz;
Nhantumbo, hoticha;
Soares, rodolfo;
Djive, helder;
Murato, ilda;
Simone, wilson;
Macete, eusebio;
Rabinovich, n regina;
Alonso, pedro;
Candrinho, baltazar;
Saúte, francisco;
Aide, pedro;
Munguambe, khátia.
Background This study aimed to capture the acceptability prior to, during and after the implementation of the first year of MDA rounds conducted under the Magude project, a malaria elimination project in southern Mozambique. Methods This was amixed-methods study, consisting of focus group discussions (FG...
Anti-Retroviral Agents/analysis,
Mass Drug Administration,
Antimalarials,
Attitude,
Health Strategies,
Residence Characteristics,
Behavior,
Knowledge,
Malaria,
Fear,
Women,
Methods,
Forecasting,
Malaria/drug therapy,
Pharmaceutical Preparations/supply & distribution,
Mozambique
Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimalarials/administration & dosage,
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/administration & dosage,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Antineoplastic Combined Chemotherapy Protocols,
Drug Resistance/genetics,
Malaria/parasitology,
Malaria/prevention & control,
Mozambique,
Plasmodium falciparum/immunology,
Plasmodium falciparum/genetics,
Plasmodium falciparum/pathogenicity,
Polymorphism, Genetic,
Protozoan Proteins/genetics,
Protozoan Proteins/metabolism,
Quinolines/administration & dosage,
Quinolines/therapeutic use,
Quinolines/pharmacology
