Background: The roll out of various public health programmes involving mass administration of medicines calls for the deployment of responsive pharmacovigilance systems to permit identification of signals of rare or even common adverse reactions. In developing countries in Africa, these systems are mostl...
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Mandomando, inácio;
Espasa, mateu;
Vallès, xavier;
Sigaúque, betuel;
Sanz, sergi;
Sacarlal, jahit;
Macete, eusébio;
Abacassamo, fátima;
Ruiz, joaquim;
Gascon, joaquim;
Kotloff, karen L;
Levine, myron.
Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhiça District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical finding...
Diarrhea/epidemiology,
Diarrhea/microbiology,
Dysentery, Bacillary/epidemiology,
Dysentery, Bacillary/microbiology,
Dysentery, Bacillary/physiopathology,
Shigella/classification,
Shigella/isolation & purification,
Mozambique/epidemiology
Background: Indoor residual spraying (IRS) has again become popular for malaria control in Africa. This combined with the affirmation by WHO that DDT is appropriate for use in the absence of longer lasting insecticide formulations in some malaria endemic settings, has resulted in an increase in IRS with ...
Environmental Monitoring,
Malaria/prevention & control,
Fumigation/methods,
Fumigation/economics,
Insecticide Resistance,
Population,
Insect Vectors,
Mosquito Control/economics,
Mosquito Control/methods,
Mozambique,
Anopheles
Endomyocardial fibrosis (EMF) mainly affects persons from Africa, South America, and Asia.1 The pathogenesis of this condition remains unknown. In advanced forms, EMF produces marked disability and carries a poor prognosis. Although there is consensus about the potential value of surgical intervention in...
Menendez, clara;
Schellenberg, david;
Macete, eusebio;
Aide, pedro;
Kahigwa, elizeus;
Sanz, sergi;
Aponte, john J;
Sacarlal, jahit;
Mshinda, hassan;
Tanner, marcel;
Alonso, pedro L.
Background: Intermittent preventive treatment (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different estimates of clinical malaria protection in two trials that used the same protocol in Ifakara, Tanzania, and Manhiça, Mozambique. Understanding the reasons for the discrepant result...
Cardiovascular Agents,
Digestive System,
Metabolism,
Respiratory System,
Blood,
Nervous System,
Anti-Bacterial Agents,
Pharmaceutical Preparations,
Anesthesia,
Therapeutics,
Pharmacy
Marijon, Eloi;
Ou, Phalla;
Celermajer, David S;
Ferreira, Beatriz;
Mocumbi, Ana Olga;
Jani, Dinesh;
Paquet, Christophe;
Jacob, Sophie;
Sidi, Daniel;
Jouven, Xavier.
Background: Epidemiologic studies of the prevalence of rheumatic heart disease have used clinical screening with echocardiographic confirmation of suspected cases. We hypothesized that echocardiographic screening of all surveyed children would show a significantly higher prevalence of rheumatic heart dis...
Malaria infection during pregnancy (MiP) is heterogeneously distributed even in malaria-endemic countries. Program planners require data to facilitate identification of highest-priority populations for MiP control. Using data from two cross-sectional studies of 5,528 pregnant women in 8 neighboring sites...
Foram analisadas a freqüência e distribuição de mutações nos genes dihidrofolato redutase e dihidropteroato sintetase do Plasmodium falciparum, usando a metodologia de reação em cadeia da polimerase e polimorfismos de hidrólise por enzimas de restrição, em amostras de sangue infectado provenie...
