Kovacs, stephanie d;
Eijk, anna maria van;
Sevene, esperanca;
Dellicour, stephanie;
Weiss, noel, s;
Emerson, scott;
Steketee, richard;
Kuile, feiko O. ter;
Stergachis, andy.
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy....
Abortion, Spontaneous,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Cohort Studies,
Malaria/drug therapy,
Pregnancy Complications, Parasitic/drug therapy,
Malaria
After the decrease in clinical malaria incidence observed in Mozambique until 2009, a steady resurgence of cases per year has been reported nationally, reaching alarming levels in 2014. However, little is known about the clinical profile of the cases presented, or the possible epidemiological factors con...
Mozambique,
Epidemiology,
Cohort Studies,
Fever,
Incidence,
Malaria,
Outpatients,
Analysis of Variance,
Seasons,
Hospitals,
Plasmodium falciparum,
Age Distribution,
Adult Children
A WHO-supported provincial-level population-based survey was conducted in 2007 to understand the determinants and implications for health of vaginal practices. A total of 919 women aged 18-60 were selected randomly for enrolment. This is the first population-based study of females in Tete Province, Mozam...
Sexual Health,
Reproductive Health/statistics & numerical data,
Sexually Transmitted Diseases,
Cohort Studies,
Surveys and Questionnaires/statistics & numerical data,
Family,
Foraminifera/microbiology,
Condoms/trends,
Abdominal Pain/parasitology,
Mozambique/epidemiology,
HIV Testing/statistics & numerical data
Tint, Halidou;
Seveno, Esperança;
Dellicour, Stephanie;
Calip, Gregory S;
D'Alessandro, Umberto;
Macete, Eusébio;
Diallo , Seydou Nakanabo;
Kazienga, Adama;
Valea, Innocent;
Sorgho, Hermann;
Valá, Anifa;
Augusto, Orvalho;
Ruperez, Clara;
Menendez, Clara;
Ouma, Peter;
Desai, Meghna;
Kuile, Feiko Ter;
Stergachis, Andy.
Background: A major unresolved safety concern for malaria case management is the use of artemisinin combination therapies (ACTs) in the first trimester of pregnancy. There is a need for human data to inform policy makers and treatment guidelines on the safety of artemisinin combination therapies (ACT) wh...
Antimalarials/adverse effects,
Artemisinins/adverse effects,
Clinical Protocols,
Cohort Studies,
Drug Administration Schedule,
Gestational Age,
Malaria/therapy,
Maternal-Fetal Exchange,
Patient Selection,
Pharmacovigilance,
Pregnancy Complications, Parasitic/therapy,
Pregnancy Outcome,
Pregnancy Trimester, First,
Prenatal Exposure Delayed Effects,
Prospective Studies,
Research Design,
Sample Size,
Mozambique,
Burkina Faso,
Kenya,
Antimalarials/therapeutic use,
Artemisinins/therapeutic use
Tuberculosis (TB) remains an important public health concern, and a leading cause of disease and death worldwide. Mozambique is one of the few high TB burden countries where TB figures have not improved in recent years, with an estimated TB incidence in 2013 of 552 cases per 100 000 population [1]. With ...
Tuberculosis/complications,
Mozambique/epidemiology,
Mortality,
Cohort Studies,
HIV Infections/complications,
HIV Infections/epidemiology,
Immunosuppression Therapy,
Incidence,
Public Health,
Rural Health,
Sputum/metabolism,
Tuberculosis/epidemiology
Thienemann, Friedrich;
Dzudie, Anastase;
Mocumbi, Ana O;
Blauwet, Lori;
Sani, Mahmoud U;
Karaye, Kamilu M;
Ogah, Okechukwu S;
Mbanze, Irina;
Mbakwem, Amam;
Udo, Patience;
Tibazarwa, Kemi;
Ibrahim, Ahmed S;
Burton, Rosie.
Introduction: Pulmonary hypertension (PH) is a devastating, progressive disease with increasingly debilitating symptoms and usually shortened overall life expectancy due to a narrowing of the pulmonary vasculature and consecutive right heart failure. Little is known about PH in Africa, but limited report...
González, raquel;
Ngoma, ghyslain mombo;
Ouédraogo, smaïla;
Kakolwa, mwaka a;
Abdulla, salim;
Accrombessi, manfred;
Aponte, john j;
Diop, daisy akerey;
Basra, arti;
Briand, valérie;
Capan, meskure;
Cot , michel;
Kabanywanyi, abdunoor m;
Kleine, christian;
Kremsner, peter g;
Macete, eusebio;
Mackanga, jean-rodolphe;
Massougbodgi, achille;
Mayor, alfredo;
Nhacolo, arsenio;
Pahlavan, golbahar;
Ramharter, michael;
Rupérez, maría;
Sevene, esperança;
Vala, anifa;
Manego, rella zoleko;
Menéndez, clara.
Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended by WHO to prevent malaria in African pregnant women. The spread of SP parasite resistance has raised concerns regarding long-term use for IPT. Mefloquine (MQ) is the most promising of avai...
Africa South of the Sahara/epidemiology,
Antimalarials/administration & dosage,
Cohort Studies,
HIV Infections,
Infant, Low Birth Weight,
Insecticide-Treated Bednets/statistics & numerical data,
Malaria/diagnosis,
Malaria/epidemiology,
Malaria/prevention & control,
Mefloquine/administration & dosage,
Pregnancy Complications, Parasitic/diagnosis,
Pregnancy Complications, Parasitic/epidemiology,
Pregnancy Complications, Parasitic/prevention & control,
Preventive Health Services/statistics & numerical data,
Treatment Outcome,
Mozambique
objectiveCommunity ART groups (CAG), peer support groups involved in community ARTdistribution and mutual psychosocial support, were piloted to respond to staggering antiretroviraltreatment (ART) attrition in Mozambique. To understand the impact of CAG on long-term retention,we estimated mortality and lo...
Mozambique,
Mortality,
Acquired Immunodeficiency Syndrome,
Psychosocial Support Systems,
Persons,
Cohort Studies,
HIV,
Residence Characteristics,
Health Services Accessibility,
Patients,
Prevalence,
World Health Organization,
Community Participation,
Medicine,
Risk Factors,
CD4 Lymphocyte Count
Dubé , Karine;
Zango, Arlinda;
Wijgert, Janneke van de;
Meque, Ivete;
Ferro, Josefo J;
Cumbe, Fidelina;
Chen, Pai Lien;
Ma, Sabrina;
Jolles, Erik;
Fumo, Afonso;
Robb, Merlin L;
Feldblum, Paul J.
Background: HIV is prevalent in Sofala Province, Mozambique. To inform future prevention research, we undertook a study in the provincial capital (Beira) to measure HIV incidence in women at higher risk of HIV and assess the feasibility of recruiting and retaining them as research participants.
Methods:...
Background: Loss to follow-up of HIV-positive patients before initiation of antiretroviral therapy can exceed 50% in low-income settings and is a challenge to the scale-up of treatment. We implemented point-of-care counting of CD4 cells in Mozambique and assessed the effect on loss to follow-up before im...
Age Factors,
Ambulatory Care,
Attitude to Health,
CD4 Lymphocyte Count,
Cohort Studies,
Confidence Intervals,
Developing Countries,
Treatment Outcome,
Patient Compliance,
Mozambique,
Retrospective Studies,
Socioeconomic Factors
