Moçambique enfrenta, actualmente, uma epidemia generalizada de HIV, onde foram estimadas cerca de de 2,2 milhões de pessoas vivendo com HIV (PVHIV), em 2018 [1]. De acordo com as estimativas de modelagem do Programa Conjunto das Nações Unidas para HIV/SIDA (ONUSIDA) de 2019, aproximadamente 56% das P...
Em 2018 Moçambique contava com cerca de 2.2 milhões de pessoas vivendo com HIV (PVHIV), e destas 55% (1.212.562) eram pacientes activos em Tratamento Antiretroviral (TARV), segundo as estimativas de modelagem do Programa Conjunto das Nações Unidas para HIV/SIDA (ONUSIDA) de 2019.
Um dos maiores desaf...
Background: There is scare information about HIV co-infections with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) among People Who Inject Drugs (PWID) in Mozambique. This information is critical to ensure the treatment necessary to decrease the progression of liver disease and the transmission o...
Hepatitis B/epidemiology,
HIV,
Substance-Related Disorders,
Viral Load,
Ambulatory Care,
Hepatitis C,
Infections,
Prevalence,
Risk Factors,
Drug Users,
Coinfection/epidemiology,
Coinfection/psychology,
Coinfection/virology,
Drug Users/psychology,
Drug Users/statistics & numerical data,
Epidemics,
HIV Infections/epidemiology,
HIV Infections/psychology,
HIV Infections/virology,
Hepacivirus,
Hepatitis B/psychology,
Hepatitis B/virology,
Hepatitis B virus,
Hepatitis C/epidemiology
Vaz, paula;
Buck, w, chris;
Bhatt, Nilesh;
Bila, Dulce;
Auld, andrew;
Houston, James;
Cossa, loide;
Alfredo, Charity;
Jobarteh, kebba;
Sabatier, jennifer.
Background: Virologic failure (VF) is highly prevalent in sub-Saharan African children on antiretroviral therapy (ART) and is often associated with human immunodeficiency virus drug resistance (DR). Most children still lack access to routine viral load (VL) monitoring for early identification of treatmen...
Anti-Retroviral Agents/therapeutic use,
Drug Resistance, Viral,
HIV/radiation effects,
HIV Infections/therapy,
HIV Infections/virology,
Lamivudine/therapeutic use,
Lamivudine/pharmacology,
Nevirapine/pharmacology,
Nevirapine/therapeutic use,
Stavudine/pharmacology,
Stavudine/therapeutic use,
Viral Load
Introduction: Viral load testing is essential to manage HIV disease, especially in infants and children. Early infant diagnosis (EID) is performed using nucleic-acid testing in children under 18 months. Resource-limited health systems face severe challenges to scale-up both viral load and EID to unpreced...
HIV Infections/diagnosis,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/isolation & purification,
HIV-1/physiology,
Infant, Newborn, Diseases/diagnosis,
Infant, Newborn, Diseases/virology,
Mozambique,
Sensitivity and Specificity,
Prospective Studies,
Viral Load/methods,
Viremia/diagnosis,
Viremia/virology
Registou-se um avanço significativo em Moçambique na prevenção da transmissão
vertical de mãe para filho (PTV), desde o lançamento do primeiro Plano de Eliminação
da Transmissão Vertical em 2012: a testagem e tratamento do HIV em mulheres grávidas
e lactantes estão totalmente integrados nos s...
Infectious Disease Transmission, Vertical,
Prevalence,
Syphilis/mortality,
Viral Load,
Syphilis/transmission,
Syphilis/prevention & control,
Syphilis/diagnosis,
Breast Feeding,
HIV,
Hepatitis B/drug therapy,
Maternal-Child Health Services/organization & administration,
Mozambique,
Health Strategies,
Syphilis/therapy
Laboratórios clínicos desempenham um papel importante no apoio ao sistema do Serviço Nacional de Saúde, proporcionando saúde de qualidade para a população moçambicana. Como parte deste sistema, os laboratórios trabalham lado a lado com outros sectores para garantir testagem apropriada para o dia...
Viral Load,
Laboratories,
National Health Systems,
Diagnostic Services,
National Health Programs,
Population,
Microbiology,
Serology,
Hematology,
Biochemistry,
Flow Cytometry,
Parasitology,
Clinical Laboratory Techniques,
Clinical Laboratory Services
Chissumbam, raquel, matavele;
Namalango, eduardo;
Maphossa, vânia;
Macicame, ivalda;
Bhatt, nilesh;
Polyak, christina;
Michael, nelson;
Jani, ilesh, v;
Kestens, luc.
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell res...
CD4-Positive T-Lymphocytes/cytology,
Flow Cytometry,
Forkhead Transcription Factors/immunology,
HIV Infections/immunology,
HIV-1/immunology,
Virus Replication,
Viral Load,
CD4-Positive T-Lymphocytes/virology,
CD4-Positive T-Lymphocytes/immunology,
HIV Infections/virology,
Ikaros Transcription Factor/genetics,
Minor Lymphocyte Stimulatory Antigens,
T-Lymphocytes, Regulatory/immunology,
T-Lymphocytes, Regulatory/virology,
Viral Replication Compartments/immunology,
Mozambique
Introduction: The scale-up of effective HIV viral load (VL) testing is an urgent public health priority. Implementation of testing is supported by the availability of accurate, nucleic acid based laboratory and point-of-care (POC) VL technologies and strong WHO guidance recommending routine testing to id...
Chang, joy;
Sousa, amina de;
Sabatier, jennifer;
Assane, mariamo;
Zhang, guoqing;
Bila, dulce;
Vaz, paula;
Alfredo, charity;
Cossa, Loide;
Bhatt, Nilesh;
Koumans, emilia, h;
Yang, chunfu;
Rivadeneira, emilia;
Jani, ilesh;
Houston, james, c.
Quantitative plasma viral load (VL) at 1000 copies /mL was recommended as the threshold to confirm antiretroviral therapy (ART) failure by the World Health Organization (WHO). Because of ongoing challenges of using plasma for VL testing in resource-limited settings (RLS), especially for children, this st...
