Background: The objective was to study the seasonal effect on the spatial distribution of the incidence of malaria in children under 10 years old living in the Manhiça district, Mozambique.
Methods: The data of the clinical malaria incidence were obtained from a study of two cohorts of children followed...
Clinical Laboratory Techniques,
Primary Health Care,
Mozambique,
HIV,
Acquired Immunodeficiency Syndrome,
Rural Population,
Maternal Health Services,
Health Impact Assessment,
Tuberculosis,
Malaria,
32395,
Data Interpretation, Statistical,
Quality Assurance, Health Care,
Health Surveillance System,
Epidemiological Monitoring,
Pregnant Women,
Public Reporting of Healthcare Data
Mayor, Alfredo;
Serra-Casas, Elisa;
Sanz, Sergi;
Aponte, João J;
Machete, eusebio;
Mandomando, Inácio;
Puyol, Laura;
Berzosa, Pedro;
Dobanã, Carlota;
Aide, pedro;
Sacarlal, jahit;
Benito, Agustín;
Alonso, Pedro;
Menendéz, Clara.
Background. Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a po tential malaria control strategy. There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to incr...
Bardají, azucena;
Sigauque, betuel;
Bruni, mlaia;
Romagosa, cleofé;
Sanz, sergi;
Mabunda, samuel;
Mandomando, inacio;
Aponte, john;
Sevene, esperança;
Alonso, pedro L;
Menéndez, clara.
Background: There is a widespread notion, based on limited information, that in areas of stable malaria transmission most pregnant women with Plasmodium falciparum infection are asymptomatic. This study aim to characterize the clinical presentation of malaria in African pregnant women and to evaluate the...
A malária é de longe a doença parasitária mais importante em Moçambique, constituindo um grave problema de saúde pública no País. Apesar de se considerar que um diagnóstico atempado e um tratamento correcto são os elementos básicos para um programa de controlo da malária bem sucedido, nas úl...
Malaria/epidemiology,
Plasmodium falciparum/parasitology,
d0006550,
Antimalarials/administration & dosage,
Malaria/prevention & control,
Malaria/diagnosis,
Amodiaquine/administration & dosage,
Chloroquine/administration & dosage,
Patients/statistics & numerical data,
Mozambique/epidemiology,
Sulfadoxine/supply & distribution,
Malaria/mortality
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Background: Indoor residual spraying (IRS) has again become popular for malaria control in Africa. This combined with the affirmation by WHO that DDT is appropriate for use in the absence of longer lasting insecticide formulations in some malaria endemic settings, has resulted in an increase in IRS with ...
Environmental Monitoring,
Malaria/prevention & control,
Fumigation/methods,
Fumigation/economics,
Insecticide Resistance,
Population,
Insect Vectors,
Mosquito Control/economics,
Mosquito Control/methods,
Mozambique,
Anopheles
Menendez, clara;
Schellenberg, david;
Macete, eusebio;
Aide, pedro;
Kahigwa, elizeus;
Sanz, sergi;
Aponte, john J;
Sacarlal, jahit;
Mshinda, hassan;
Tanner, marcel;
Alonso, pedro L.
Background: Intermittent preventive treatment (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different estimates of clinical malaria protection in two trials that used the same protocol in Ifakara, Tanzania, and Manhiça, Mozambique. Understanding the reasons for the discrepant result...
Macete, Eusébio V;
Sacarlal, Jahit;
Aponte, John J;
Leach, Amanda;
Navia, Margarita M;
Milman, Jessica;
Guinovart, Caterina;
Mandomando, Inácio;
López-Púa, Yolanda;
Lievens, Marc;
Ofori, Alex Owusu;
Dubois, Marie-Claude;
Cahill, Conor P;
Koutsoukos, Marguerite;
Sillman, Marla;
Thompson, Ricardo;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
Results: Both vaccines were safe and had similar reactogenicity profiles. All subjects with paired pre and post-vaccination
samples showed a vaccine response with respect to anti-circumsporozoite (CS) antibodies irrespective of initial anti-CS
serostatus. Geometric mean titers (GMTs) were 191 EU/ml (95...
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
