Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...
Mozambique,
Infections,
HIV-1/growth & development,
Circumcision, Male,
Molecular Sequence Data,
Polymorphism, Genetic,
Treatment Failure,
Sequence Analysis, DNA,
Genotype,
Drug Resistance, Viral,
HIV Infections
Human milk and infant gut microbiota are essential for the immune system maturation and protection against infections. There is scarce information on the microbiological composition of breast milk in general, and none from developing countries. The objective of the study was to characterize the breast mi...
Bacteria/classification,
Bacteria/genetics,
Black People,
Coinfection,
Cross-Sectional Studies,
Feces/microbiology,
Gastrointestinal Tract/microbiology,
HIV Infections/epidemiology,
Lactation,
Microbiota,
Milk, Human/microbiology,
Milk, Human/virology,
Mothers,
Prevalence,
Mozambique
Liotta, Giuseppe;
Mancinelli, Sandro;
Nielsen-Saines, Karin;
Gennaro, E;
Abdul Magid, Nurja;
Germano, Paola;
Jere, Haswell;
Guidotti, Gianni;
Buonomo, Ersilia;
Ciccacci, Fausto;
Palombi, Leonardo;
Marazzi, Maria Cristina.
HIV infection is a major contributor to maternal mortality in resource-limited settings. The Drug Resource Enhancement Against AIDS and Malnutrition Programme has been promoting HAART use during pregnancy and postpartum for Prevention-of-mother-to-child-HIV transmission (PMTCT) irrespective of maternal C...
Antiretroviral Therapy, Highly Active,
CD4 Lymphocyte Count,
Follow-Up Studies,
HIV Infections,
Infectious Disease Transmission, Vertical,
Kaplan-Meier Estimate,
Maternal Mortality,
Mozambique/epidemiology,
Multivariate Analysis,
Outcome Assessment, Health Care,
Pregnancy Complications, Infectious,
Survival Rate,
Proportional Hazards Models,
Pregnant Women,
Viral Load
Introduction: Delayed uptake of clinical services impedes favorable clinical outcomes in Mozambique. Care is delayed among patients who initiate care with traditional healers; patients with conditions like human immunodeficiency virus (HIV) or tuberculosis are rarely referred to the health system in a ti...
d0019960,
HIV Infections/epidemiology,
HIV Infections/therapy,
Health Education,
d0082880,
d0149440,
Health Facilities,
Health Systems/organization & administration,
Medicine, African Traditional,
Referral and Consultation/statistics & numerical data,
Rural Population/statistics & numerical data,
Information Storage and Retrieval
Bila, Dolce Celina Adolfo;
Young, Peter;
Marks, Herriet;
Vubil, Adolfo Salvador;
Mahumed, Mussagy;
Brooks, James I;
Augusto, Angelo;
Jani, Ilesh Vinodrai;
Mabunda, Nédio Jonas;
Tanuri, Amilcar;
Abreu, Celina Monteiro.
Em Moçambique, o tratamento anti-retroviral altamente activo (HAART) foi introduzido em 2004, seguido de descentralização e expansão, resultando num aumento de mais de 20 vezes na cobertura até 2009. A implementação de inquéritos sobre limiares de resistência aos medicamentos contra o VIH (HIVDR...
Mozambique through the prevention of mother-to-child transmission (PMTCT) program. If routine data from this program were of sufficient quality, their heightened coverage and continuous availability could complement or even replace biannual sentinel serosurveys that currently serve as the primary HIV sur...
HIV Infections/diagnosis,
HIV Infections/prevention & control,
HIV Infections/epidemiology,
Sentinel Surveillance,
HIV Infections/transmission,
Infectious Disease Transmission, Vertical/prevention & control,
Infectious Disease Transmission, Vertical/statistics & numerical data,
Mozambique/epidemiology,
Pregnancy Complications, Infectious/diagnosis,
Pregnancy Complications, Infectious/epidemiology,
Pregnancy Complications, Infectious/prevention & control,
Pregnancy Complications, Infectious/virology
Background: The prevalence and determinants of HIV and late diagnosis of HIV in young women in Beira, Mozambique, were estimated in preparation for HIV prevention trials.
Methods: An HIV prevalence survey was conducted between December 2009 and October 2012 among 1,018 women aged 18-35 with two or more ...
Toxoplasmose é uma doença parasitária causada por Toxoplasma gondii (T. gondii). O T. gondii, em pacientes imunocompetentes, geralmente causa infecções assintomáticas e latentes. Em doentes imunocomprometidos, a reactivação de toxoplasmose latente no Sistema Nervoso Central (SNC), pode causar doe...
Toxoplasmosis, Cerebral,
Mozambique,
Diagnostic Techniques, Neurological/standards,
HIV Infections,
Toxoplasmosis, Cerebral/prevention & control,
Toxoplasmosis/transmission,
Molecular Diagnostic Techniques,
Encephalitis,
Toxoplasmosis, Congenital
In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at full dose) with an ef...
AIDS-Related Opportunistic Infections/therapy,
Anti-HIV Agents/administration & dosage,
Anti-HIV Agents/therapeutic use,
Anti-HIV Agents/radiation effects,
Antitubercular Agents/therapeutic use,
Benzoxazines/therapeutic use,
Benzoxazines/administration & dosage,
Benzoxazines/adverse effects,
Coinfection,
Cyclopropanes,
Drug Interactions,
Drug Therapy, Combination,
HIV Infections/therapy,
Nevirapine/therapeutic use,
Nevirapine/adverse effects,
Nevirapine/administration & dosage,
Treatment Outcome,
Tuberculosis/complications,
Tuberculosis/therapy,
Tuberculosis, Pulmonary/complications,
Tuberculosis, Pulmonary/therapy,
Mozambique/epidemiology
Background: Opt-out HIV testing is offered at 70% of antenatal care (ANC) clinics in Mozambique through the
prevention of mother-to-child transmission (PMTCT) program. If routine data from this program were of sufficient
quality, their heightened coverage and continuous availability could complement or e...
HIV Infections/diagnosis,
HIV Infections/epidemiology,
HIV Infections/prevention & control,
Infectious Disease Transmission, Vertical/prevention & control,
Infectious Disease Transmission, Vertical/statistics & numerical data,
Mozambique/epidemiology,
Pregnancy Complications, Infectious/diagnosis,
Pregnancy Complications, Infectious/epidemiology,
Pregnancy Complications, Infectious/prevention & control,
Pregnancy Complications, Infectious/virology,
Prevalence,
Sentinel Surveillance
