Peter, trevor;
Ellenberger, dennis;
Boeras, debrah;
Kim, andrea A;
Messele, tsehaynesh;
Roberts, teri;
Stevens, wendy;
Jani, ilesh;
Abimiku, alash'le;
Ford , nathan;
Katz, Zachary;
Nkengasong, john N.
Scaling up access to HIV viral load testing for individuals undergoing antiretroviral therapy in low-resource settings is a global health priority, as emphasised by research showing the benefits of suppressed viral load for the individual and the whole population. Historically, large-scale diagnostic tes...
Anti-HIV Agents/therapeutic use,
Antiretroviral Therapy, Highly Active/methods,
Drug Monitoring,
HIV Infections/drug therapy,
Health Policy,
Medical Laboratory Science,
Blood/virology,
Desiccation/methods,
Global Health,
HIV Infections/prevention & control,
HIV Infections/virology,
Medical Laboratory Science/organization & administration,
Specimen Handling/methods,
Viral Load
Meggi, Bindiya;
Bollinger, Timothy;
Mabunda, Nédio;
Vubil, Adolfo;
Tobaiwa, Ocean;
Quevedo, Jorge I;
Loquiha, Osvaldo;
Vojnov, Lara;
Peter, Trevor F;
Jani, Ilesh V.
The long delay in returning test results during early infant diagnosis of HIV (EID) often
causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited
settings. A point-of-care (POC) test may help overcome these challenges. We evaluated
the performance of the LYNX p24 A...
Anti-HIV Agents/therapeutic use,
Early Diagnosis,
HIV Infections/diagnosis,
HIV Infections/therapy,
HIV Infections/epidemiology,
HIV Infections/immunology,
Point-of-Care Testing/standards,
Reproducibility of Results,
Mozambique/epidemiology,
Sensitivity and Specificity,
HIV-1/immunology
Raquel Gonzalez and colleagues highlight an urgent need to evaluate antimalarials that can be safely administered to HIV-infected pregnant women on antiretroviral treatment and cotrimoxazole prophylaxis.
African HIV-infected pregnant women are the most vulnerable population group to
malaria infection.
...
Objectives: We describe nevirapine and efavirenz exposure on and off tuberculosis treatment and consequences for virological efficacy and tolerance in patients included in the ANRS 12146/12214-CARINEMO trial.
Methods: Participants were randomly selected to receive either nevirapine at 200 mg twice daily...
Alkynes,
Antiretroviral Therapy, Highly Active/methods,
Antitubercular Agents/therapeutic use,
Benzoxazines/therapeutic use,
Cyclopropanes,
HIV Infections/therapy,
Drug Tolerance,
Anti-HIV Agents/therapeutic use,
Infections/complications,
Nevirapine/therapeutic use,
Tuberculosis/therapy,
Tuberculosis/complications,
Treatment Outcome,
Mozambique
Elul, batya;
Lahuerta, maria;
Abacassamo, Fatima;
Lamb, matthew, r;
Ahoua, laurence;
McNairy, margaret, l;
Tomo, Maria;
Horowitz, deborah;
Sutton, roberta;
Mussa, antonio;
Gurr, danielle;
Jani, ilesh, v.
Background: Despite the extraordinary scale up of HIV prevention, care and treatment services in sub-Saharan Africa (SSA) over the past decade, the overall effectiveness of HIV programs has been significantly hindered by high levels of attrition across the HIV care continuum. Data from “real-life” se...
Anti-HIV Agents/therapeutic use,
HIV Infections/diagnosis,
CD4 Lymphocyte Count,
Mozambique,
Clinical Protocols,
Anti-HIV Agents,
HIV Infections/therapy,
HIV Infections/immunology,
Patient Compliance,
Catchment Area, Health
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...
HIV-1/genetics,
Amino Acid Sequence,
Anti-HIV Agents,
Cluster Analysis,
Drug Resistance, Viral,
Enfuvirtide,
Genotype,
HIV Envelope Protein gp41/genetics,
HIV Infections/virology,
HIV-1/classification,
Molecular Sequence Data,
Mozambique,
Mutation, Missense,
Peptide Fragments,
Phylogeny,
Polymorphism, Genetic,
RNA, Viral,
Sequence Alignment,
Sequence Analysis, DNA,
Treatment Failure
Ao longo de algumas décadas, a epidemia do HIV e SIDA tornou-se num ícone de grandes questões que afligem o mundo devido a sua dinâmica que configura suas manifestações de acordo com as características culturais e sócio demográficas em diferentes populações. O HIV e SIDA constitui um dos grand...
Adaptation, Psychological,
HIV/immunology,
Anti-Retroviral Agents/supply & distribution,
Anti-HIV Agents/supply & distribution,
Acquired Immunodeficiency Syndrome,
HIV Seropositivity/epidemiology,
HIV,
Demography/statistics & numerical data,
Mozambique,
HIV/drug effects
Stigma has been implicated in poor outcomes of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) care. Reducing stigma is important for HIV prevention and long-term treatment success. Although stigma reduction interventions are conducted in Mozambique, little is known about the...
Acquired Immunodeficiency Syndrome/epidemiology,
Acquired Immunodeficiency Syndrome/psychology,
Anti-HIV Agents/therapeutic use,
Consensus,
HIV Seropositivity/psychology,
HIV Seropositivity/epidemiology,
Social Stigma,
Health Services Needs and Demand,
Health Knowledge, Attitudes, Practice,
Health Personnel,
Mozambique/epidemiology
Background: The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown.
Objectives: This study was conducted with the aim to ...
Anti-HIV Agents/therapeutic use,
DNA, Viral/genetics,
HIV Infections/complications,
Hepatitis B/complications,
Hepatitis B/diagnosis,
Hepatitis B virus/genetics,
Mozambique,
Hepatitis B virus/isolation & purification,
d0065140,
Viral Load
Bila, Dulce Celina Adolfo;
Young, Pedro;
Merks, Harriet;
Vubil, Adolfo Salvador;
Mahomed, Mussagy;
Augusto, Angelo;
Abreu, Celina Monteiro;
Mabunda, Nédio Jonas;
Brooks, James, I;
Tanuri, Amilcar;
Jani, Ilesh Vinodrai.
Objective: InMozambique, highly active antiretroviral treatment (HAART) was introduced in 2004 followed by decentralizationandexpansion, resulting inamorethan20-fold increase incoverageby2009. ImplementationofHIV drugresistancethresholdsurveys (HIVDR-TS) iscrucial inorder tomonitor theemergenceof transmi...
Anti-HIV Agents/pharmacology,
Anti-HIV Agents/therapeutic use,
Antiretroviral Therapy, Highly Active,
Mozambique,
Drug Resistance, Viral/genetics,
HIV Infections/therapy,
HIV Infections/epidemiology,
HIV Infections/virology,
HIV-1/classification,
HIV-1/radiation effects,
HIV-1/genetics,
Mozambique/epidemiology,
Mutation,
Phylogeny
