RDSM – Rede de Documentação sobre Saúde em Moçambique

Risk of extended viral resistance in human immunodeficiency virus-1-infected Mozambican children after first-line treatment failure

Vaz, paula; Chaix, marie-laure; Jani, ilesh; Macassa, eugenia; Bila, Dulce; Vubil, Adolfo; Anderson, Soren; Rouzioux, christine, pharmD; Briand, nelly; Blanche, stephane.

Pediatr. infect. dis. j; 28 (12), 2009

Background: Resistant virus may be selected by sub-optimal control of HIV-1 replication during antiretroviral treatment. The incidence and profile of resistance in children receiving World Health Organization-recommended treatment remains to be evaluated on a large scale. Goals: Assessment of the frequen...

Drug Resistance, HIV-1/genetics, Anti-HIV Agents, HIV Infections/blood, Virus Replication, Analysis of Variance, HIV-1/physiology, HIV Infections/therapy, HIV Infections/virology, Reverse Transcriptase Inhibitors/pharmacology, Reverse Transcriptase Inhibitors/therapeutic use, Anti-HIV Agents/pharmacology, Anti-HIV Agents/therapeutic use, Treatment Failure, Mozambique

Fulltext

Molecular Epidemiology and Trends in HIV-1 Transmitted Drug Resistance in Mozambique 1999–2018

Viruses; 14 (9), 1992

HIV drug resistance (HIVDR) can become a public health concern, especially in low- and middle-income countries where genotypic testing for people initiating antiretroviral therapy (ART) is not available. For first-line regimens to remain effective, levels of transmitted drug resistance (TDR) need to be m...