Kovacs, stephanie d;
Eijk, anna maria van;
Sevene, esperanca;
Dellicour, stephanie;
Weiss, noel, s;
Emerson, scott;
Steketee, richard;
Kuile, feiko O. ter;
Stergachis, andy.
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy....
Abortion, Spontaneous,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Cohort Studies,
Malaria/drug therapy,
Pregnancy Complications, Parasitic/drug therapy,
Malaria
Adjei, aexander;
Bana, solomon narh;
Amu, alberta;
Kukula, vida;
Nagai, richard afedi;
Agyei, seth owusu;
Oduro, abraham;
Macete, Eusebio;
Abdulla, salim;
Halidou, tinto;
Sie, ali;
Osei, isaac;
Sevene, esperance;
Asante, kwaku-poku;
Mulokozi, abdunoor;
Compaore, guillaume;
Valea, innocent;
Adjuik, martin;
Baiden, rita;
Ogutu, Bernhards;
Binka, fred;
Gyapong, margaret.
Background: Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. However, little was known on its post-registration safety and effectiveness in sub-Saharan Africa. DHA-PQ provides a long post-treatment pro...
Tint, Halidou;
Seveno, Esperança;
Dellicour, Stephanie;
Calip, Gregory S;
D'Alessandro, Umberto;
Macete, Eusébio;
Diallo , Seydou Nakanabo;
Kazienga, Adama;
Valea, Innocent;
Sorgho, Hermann;
Valá, Anifa;
Augusto, Orvalho;
Ruperez, Clara;
Menendez, Clara;
Ouma, Peter;
Desai, Meghna;
Kuile, Feiko Ter;
Stergachis, Andy.
Background: A major unresolved safety concern for malaria case management is the use of artemisinin combination therapies (ACTs) in the first trimester of pregnancy. There is a need for human data to inform policy makers and treatment guidelines on the safety of artemisinin combination therapies (ACT) wh...
Antimalarials/adverse effects,
Artemisinins/adverse effects,
Clinical Protocols,
Cohort Studies,
Drug Administration Schedule,
Gestational Age,
Malaria/therapy,
Maternal-Fetal Exchange,
Patient Selection,
Pharmacovigilance,
Pregnancy Complications, Parasitic/therapy,
Pregnancy Outcome,
Pregnancy Trimester, First,
Prenatal Exposure Delayed Effects,
Prospective Studies,
Research Design,
Sample Size,
Mozambique,
Burkina Faso,
Kenya,
Antimalarials/therapeutic use,
Artemisinins/therapeutic use
Baiden, Rita;
Oduro, Abraham;
Halidou, Tinto;
Gyapong, Margaret;
Sie, Ali;
Macete, Eusebio;
Abdulla, Salim;
Agyei, Seth Owusu;
Mulokozi, Abdunoor;
Adjei , Alex 10;
Sevene, Esperanca;
Compaore, Guillaume;
Valea, Innocent;
Osei, Isaac;
Yawson, Abena;
Adjuik, Martin;
Akparibo, Raymond;
Ogutu, Bernhards;
Upunda, Gabriel Leonard;
Smith, Peter;
Binka, Fred.
Background: The World Health Organization recommends artemisinin-based combination (ACT) for the treatment of uncomplicated malaria. Post-licensure safety data on newly registered ACT is critical for evaluating their risk/benefit profile in malaria endemic countries. The clinical safety of the newly regi...
González, raquel;
Ngoma, ghyslain mombo;
Ouédraogo, smaïla;
Kakolwa, mwaka a;
Abdulla, salim;
Accrombessi, manfred;
Aponte, john j;
Diop, daisy akerey;
Basra, arti;
Briand, valérie;
Capan, meskure;
Cot , michel;
Kabanywanyi, abdunoor m;
Kleine, christian;
Kremsner, peter g;
Macete, eusebio;
Mackanga, jean-rodolphe;
Massougbodgi, achille;
Mayor, alfredo;
Nhacolo, arsenio;
Pahlavan, golbahar;
Ramharter, michael;
Rupérez, maría;
Sevene, esperança;
Vala, anifa;
Manego, rella zoleko;
Menéndez, clara.
Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended by WHO to prevent malaria in African pregnant women. The spread of SP parasite resistance has raised concerns regarding long-term use for IPT. Mefloquine (MQ) is the most promising of avai...
Africa South of the Sahara/epidemiology,
Antimalarials/administration & dosage,
Cohort Studies,
HIV Infections,
Infant, Low Birth Weight,
Insecticide-Treated Bednets/statistics & numerical data,
Malaria/diagnosis,
Malaria/epidemiology,
Malaria/prevention & control,
Mefloquine/administration & dosage,
Pregnancy Complications, Parasitic/diagnosis,
Pregnancy Complications, Parasitic/epidemiology,
Pregnancy Complications, Parasitic/prevention & control,
Preventive Health Services/statistics & numerical data,
Treatment Outcome,
Mozambique
González, Raquel;
Desai, Meghna;
Macete 3, Eusebio;
Ouma, Peter;
Kakolwa, Mwaka A;
Abdulla, Salim;
Aponte, John J;
Bulo, Helder;
Kabanywanyi, Abdunoor M;
Katana, Abraham;
Maculuve, Sonia;
Mayor, Alfredo;
Nhacolo, Arsenio;
Otieno, Kephas;
Pahlavan, Golbahar;
Rupérez, María;
Sevene, Esperança;
Slutsker, Laurence;
Vala, Anifa;
Williamsom, John;
Menéndez, Clara.
Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women taking daily cotrimoxazole prophylaxis (CTXp) because of potential added risk of adve...
Antimalarials/administration & dosage,
Double-Blind Method,
Follow-Up Studies,
HIV Infections/diagnosis,
HIV Infections/drug therapy,
HIV Infections/epidemiology,
Infectious Disease Transmission, Vertical/prevention & control,
Malaria/diagnosis,
Malaria/epidemiology,
Malaria/prevention & control,
Mefloquine/administration & dosage,
Pregnancy Complications, Infectious/diagnosis,
Pregnancy Complications, Infectious/epidemiology,
Pregnancy Complications, Infectious/prevention & control,
Pregnancy Complications, Parasitic/diagnosis,
Pregnancy Complications, Parasitic/epidemiology,
Pregnancy Complications, Parasitic/prevention & control,
Pregnancy Outcome,
Mozambique/epidemiology,
Tanzania/epidemiology,
Kenya/epidemiology,
Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage
Nhama, Abel;
Bassat 1, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunateamodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentre...
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Artesunate/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Mozambique/epidemiology
Nhama, Abel;
Bassat, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentr...
Amodiaquine/adverse effects,
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Fluorenes/adverse effects,
Fluorenes/therapeutic use,
Kaplan-Meier Estimate,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Treatment Outcome,
Mozambique/epidemiology
As infecções pelo Plasmodium falciparum (P.falciparum) e pelo Vírus da Imunodeficiência Humana (HIV) constituem problema de Saúde Pública particularmente na África subsaariana onde as duas infecções têm o seu maior peso. A sobreposição geográfica das duas infecções implica a ocorrência da...
Plasmodium falciparum,
HIV Infections,
Malaria/complications,
Malaria/diagnosis,
Patients,
T-Lymphocytopenia, Idiopathic CD4-Positive,
Genetic Variation,
Merozoites,
Mozambique,
Antimalarials/immunology,
CD4 Antigens
Quelhas, Diana;
Puyol, Laura;
Quinto, Llorenç;
Nhsmpossa, Tacilta;
Casas, Elisa Serra;
Macete, Eusébio;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Doolan, Denise L;
Menendez, Clara;
Dobano, Carlota.
Cytokines and chemokines are key mediators of anti-malarial immunity. We evaluated whether Intermittent Preventive Treatment in infants with Sulfadoxine-Pyrimethamine (IPTi-SP) had an effect on the acquisition of these cellular immune responses in Mozambican children. Multiple cytokines and chemokines we...
