Background: Depending on the presence of mutations that determine isoniazid (INH) susceptibility (katG and inhA), Mycobacterium tuberculosis may be susceptible to high doses of INH or ethionamide (ETH).
Objective: To describe the INH resistance profile and association of katG mutation with previous INH ...
A tuberculose (TB) é uma doença infecciosa que ameaça a humanidade há séculos. Recentemente grandes
avanços foram conseguidos no combate à tuberculose, entretanto a resistência bacilar e a coinfecção pelo
Vírus de Imunodeficiência Humana (HIV) persistem como os principais desafios dos program...
Drug Resistance, Bacterial,
Mycobacterium tuberculosis/drug effects,
Genotype,
Antibiotics, Antitubercular/pharmacology,
Coinfection,
Tuberculosis, Multidrug-Resistant/microbiology,
Prevalence,
Tuberculosis/microbiology,
Microbial Sensitivity Tests,
Mycobacterium tuberculosis/genetics,
HIV Infections/epidemiology,
Mozambique/epidemiology
López-Varela, Elisa;
Augusto, Orvalho Joaquim;
Guerra, Luis;
Respeito, Durval;
Sacoor, Charfudin;
Sacarlal, Jahit;
Migliori, Giovanni Battista;
Sotgiu, Giovanni;
Alonso, Pedro L;
García-Basteiro, Alberto L.
Two core indicators adopted for evaluating tuberculosis (TB) control programmes are treatment outcome and case detection rate (CDR). While the former is easy to report, the CDR can only be estimated (calculated as notifications of new and relapse cases divided by estimated incidence). According to the Wo...
Mozambique is one of the high burden tuberculosis (TB) and human immunodeficiency virus
(HIV) countries with a prevalence of HIV infection in adults of 11.5% and an estimated TB
prevalence of 559 per 100 000 population. Fifty six percent of the TB patients in
Mozambique are estimated to be HIV positive. ...
This is a substudy of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146-CARINEMO) trial, which assessed the pharmacokinetics of rifampin or isoniazid with or without the coadm...
HIV/drug effects,
Antitubercular Agents/administration & dosage,
Benzoxazines,
Mycobacterium,
Mycobacterium tuberculosis/drug effects,
Tuberculosis/drug therapy,
Acquired Immunodeficiency Syndrome/epidemiology,
HIV Seroprevalence/trends,
Hepatitis/diagnosis,
CD4 Antigens/drug effects,
Mozambique/epidemiology
We evaluate the performance of the TBcID assay in a panel of 100 acid-fast bacilli cultures. Sixty-four isolates were TBcID positive for Mycobacterium tuberculosis complex (MTBC), whereas 36 gave negative results. These included 28 nontuberculous mycobacteria, one nonmycobacterial isolate, one M. tubercu...
Viegas, sofia omar;
Machado, adelina;
Groenheit, Ramona;
Ghebremichael, solomon;
Pennhag, alexandra;
Gudo, eduardo samo;
Cuna, zaina;
Langa, egídio;
Miotto, paolo;
Cirillo, Daniela, M.
The Beijing genotype is a lineage of Mycobacterium tuberculosis that is distributed worldwide and responsible for large epidemics, associated with multidrug-resistance. However, its distribution in Africa is less understood due to the lack of data. Our aim was to investigate the prevalence and possible t...
Mycobacterium tuberculosis,
AIDS-Related Opportunistic Infections/epidemiology,
AIDS-Related Opportunistic Infections/microbiology,
Coinfection/epidemiology,
Mozambique,
Coinfection/microbiology,
Mycobacterium tuberculosis/genetics,
Polymorphism, Restriction Fragment Length,
Tuberculosis, Multidrug-Resistant/genetics,
Tuberculosis, Pulmonary/microbiology
Multiple-locus variable-number tandem repeat analysis (MLVA) is useful to establish transmission routes and sources of infections for various microorganisms including Mycobacterium tuberculosis complex (MTC). The recently released SITVITWEB database contains 12-loci Mycobacterial Interspersed Repetitive ...
Bacterial Typing Techniques,
Bayes Theorem,
Genetic Loci/genetics,
Genotype,
Internationality,
Interspersed Repetitive Sequences/genetics,
Microsatellite Repeats/genetics,
Mycobacterium tuberculosis/classification,
Mycobacterium tuberculosis/genetics,
Phylogeny,
Phylogeography
Viegas, sofia omar;
Ghebremichael, solomon;
Massawo, leguesse;
Alberto, Matos;
Fernandes, fabíola couto;
Couvin, david;
Matavele, josé maiane;
Rastogi, Nalin;
Neves, Margarida Correia;
Machado, adelina.
Background: The zoonosis bovine tuberculosis (TB) is known to be responsible for a considerable proportion of extrapulmonary TB. In Mozambique, bovine TB is a recognised problem in cattle, but little has been done to evaluate how Mycobacterium bovis has contributed to human TB. We here explore the public...
Viegas, sofia omar;
Machado, adelina;
Groenheit, Ramona;
Ghebremichael, solomon;
Pennhag, alexandra;
Gudo, paula, s;
Cuna, zaina;
Langa, egídio;
Miotto, paolo;
Cirillo, Daniela, M.
Background: Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of Mycobacterium tuberculosis circulating in the country are important to better understand the epidemic. This study determined the predominant s...
