In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at full dose) with an ef...
AIDS-Related Opportunistic Infections/therapy,
Anti-HIV Agents/administration & dosage,
Anti-HIV Agents/therapeutic use,
Anti-HIV Agents/radiation effects,
Antitubercular Agents/therapeutic use,
Benzoxazines/therapeutic use,
Benzoxazines/administration & dosage,
Benzoxazines/adverse effects,
Coinfection,
Cyclopropanes,
Drug Interactions,
Drug Therapy, Combination,
HIV Infections/therapy,
Nevirapine/therapeutic use,
Nevirapine/adverse effects,
Nevirapine/administration & dosage,
Treatment Outcome,
Tuberculosis/complications,
Tuberculosis/therapy,
Tuberculosis, Pulmonary/complications,
Tuberculosis, Pulmonary/therapy,
Mozambique/epidemiology
Van der Meeren, Birgitta Theodora;
Chhaganlal, Kajal D;
Pfeiffer, Annett;
Gomez, Ermelinda;
Ferro, Josefo J;
Hilbink, Mirrian;
Steidel, Konrad;
Macome, Cesar;
Vondervoort, Francien J;
Wever, Peter C.
Objectives: A prospective surveillance study was conducted to investigate the epidemiology and patterns of antibiotic resistance among uropathogens from hospitalised children in Beira, Mozambique. Additionally, information regarding determinants of a urinary tract infection (UTI) was obtained.
Methods: ...
Anti-Infective Agents/therapeutic use,
Child, Hospitalized,
Drug Resistance, Microbial,
Microbial Sensitivity Tests,
Urinalysis,
Urinary Tract Infections/epidemiology,
Urinary Tract Infections/drug therapy,
Urinary Tract Infections/microbiology,
Mozambique/epidemiology
Background: Opt-out HIV testing is offered at 70% of antenatal care (ANC) clinics in Mozambique through the
prevention of mother-to-child transmission (PMTCT) program. If routine data from this program were of sufficient
quality, their heightened coverage and continuous availability could complement or e...
HIV Infections/diagnosis,
HIV Infections/epidemiology,
HIV Infections/prevention & control,
Infectious Disease Transmission, Vertical/prevention & control,
Infectious Disease Transmission, Vertical/statistics & numerical data,
Mozambique/epidemiology,
Pregnancy Complications, Infectious/diagnosis,
Pregnancy Complications, Infectious/epidemiology,
Pregnancy Complications, Infectious/prevention & control,
Pregnancy Complications, Infectious/virology,
Prevalence,
Sentinel Surveillance
Stigma has been implicated in poor outcomes of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) care. Reducing stigma is important for HIV prevention and long-term treatment success. Although stigma reduction interventions are conducted in Mozambique, little is known about the...
Acquired Immunodeficiency Syndrome/epidemiology,
Acquired Immunodeficiency Syndrome/psychology,
Anti-HIV Agents/therapeutic use,
Consensus,
HIV Seropositivity/psychology,
HIV Seropositivity/epidemiology,
Social Stigma,
Health Services Needs and Demand,
Health Knowledge, Attitudes, Practice,
Health Personnel,
Mozambique/epidemiology
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming an important arget antiretroviral therapy. Raltegravir was the first integrase inhibitor approved for use in HIV therapy andelvitegravir is in the late phase of clinical development; both show good results in monot...
DNA, Viral/chemistry,
DNA, Viral/genetics,
Drug Resistance, Viral,
Genetic Variation,
HIV Infections/virology,
HIV Integrase/genetics,
HIV Integrase Inhibitors/therapeutic use,
Molecular Sequence Data,
Proviruses/genetics,
Mutation, Missense,
Mozambique/epidemiology,
Sequence Analysis, DNA/instrumentation
Tuberculosis (TB) presents a serious problem in Mozambique. HIV prevalence among TB patients is estimated at 47%. A delay in having their first CD4+ cell count could lead to a missed opportunity for ART initiation due to a CD4+ cell increase above the cut-off caused by TB treatment. The objective is to d...
HIV Seropositivity/immunology,
Confidence Intervals,
CD4 Lymphocyte Count,
Anti-Retroviral Agents/therapeutic use,
Mozambique/epidemiology,
HIV Seropositivity/therapy,
Tuberculosis, Pulmonary/therapy,
CD4-Positive T-Lymphocytes/radiation effects,
Tuberculosis, Pulmonary/immunology
Background: Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual.
Methods: A cross-sectional study among HIV-1 infected and uninfected populations...
Mirabel, Mariana;
Celermajer, David S;
Ferreira, Beatriz;
Tafflet, Muriel;
Perier, Marie-Cécile;
Karam, Nicole;
Mocumbi, Ana-Olga;
Jani, Dinesh N;
Sidi, Daniel;
Jouven, Xavier;
Marijon, Eloi.
Aims: Portable echocardiography has emerged as a potential tool to detect rheumatic heart disease (RHD) early. Complex echocardiographic criteria used in recent epidemiological studies may be difficult to translate into daily practice in areas where the burden of RHD is greatest and skilled practitioners...
Reményi, Bo;
Wilson, Nigel;
Kado, Joseph;
Amrita, Krishna Kumar;
Lawrenson, John;
Maguire, Graeme;
Marijon, Eloi;
Mirabel, Mariana;
Mocumbi, Ana Olga;
Mota, Cleonice;
Paar, John;
Saxena, Anita;
Scheel, Janet;
Stirling, John;
Viali, Satupaitea;
Balekundri, Vijayalakshmi I;
Wheaton, Gavin;
Zühlke, Liesl;
Carapetis, Jonathan.
Over the past 5 years, the advent of echocardiographic screening for rheumatic heart disease (RHD) has revealed a higher RHD burden than previously thought. In light of this global experience, the development of new international echocardiographic guidelines that address the full spectrum of the rheumati...
Background: African countries are scaling up malaria interventions, especially insecticide treated nets (ITN) and indoor residual spraying (IRS), for which ambitious coverage targets have been set. In spite of these efforts infection prevalence remains high in many parts of the continent. This study inve...
