Background: Co-infection with falciparum malaria and HIV-1 increases the severity and mortality of both infections in unstable malaria-transmission areas. In contrast, in stable transmission areas, HIV co-infection increases the severity of both infections but has not been found to influence malaria mort...
Plasmodium falciparum/isolation & purification,
Coinfection/complications,
Coinfection/epidemiology,
Coinfection/mortality,
HIV Infections/complications,
HIV Infections/epidemiology,
HIV Infections/mortality,
HIV-1/isolation & purification,
Malaria, Falciparum/complications,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/mortality,
Parasitemia/complications,
Parasitemia/epidemiology,
Parasitemia/mortality,
Risk Factors,
Prospective Studies,
Mozambique/epidemiology
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...
Mozambique,
Infections,
HIV-1/growth & development,
Circumcision, Male,
Molecular Sequence Data,
Polymorphism, Genetic,
Treatment Failure,
Sequence Analysis, DNA,
Genotype,
Drug Resistance, Viral,
HIV Infections
Desde que a síndrome de imunodeficiência adquirida (sida) foi descrita pela primeira vez em 1981, a infecção pelo vírus da imunodeficiência humana (hiv) tornou-se uma epidemia global. Embora os usuários de drogas intravenosas, hemofílicos, fetos de mães contaminadas e receptores de transfusão c...
Desde que a síndrome de imunodeficiência adquirida (SIDA) foi descrita pela primeira vez em 1981, a infecção pelo vírus da imunodeficiência humana (HIV) tornou-se uma epidemia global. Embora os usuários de drogas intravenosas, hemofílicos, fetos de mães contaminadas e receptores de transfusão c...
Jani, Ilesh;
Sebastian, Jennifer;
Vubil, Adolfo;
Subbarao, Shambavi;
Bila, Dolce;
Sousa, Amina;
Mabunda, Nédio;
Garcia, Albert;
Ellemberger, Dennis;
Ramos, Artur;
Skaggs, Beth.
We performed a comparative analysis between Roche Amplicor HIV-1 DNA test and CAPTAQ assay for the detection of HIV in 830 dried blood spot (DBS) pediatric samples collected in Mozambique. Our results demonstrated no statistical difference between these assays. The CAPTAQ assay approached nearly 100% rep...
Oliveira, Michelli, F;
Ramalho, Dulce, B;
Abreu, Celina, M;
Vubil, Adolfo Salvador;
Mabunda, Nédio;
Ismael, Nalia;
Francisco, Cidia;
Jani, Ilesh, V;
Tanuri, Amilcar.
HIV proviral DNA integration into the host chromosome is carried out by integrase becoming an important target antiretroviral therapy. Raltegravir was the first integrase inhibitor approved for use in HIV therapy and elvitegravir is in the late phase of clinical development; both show good results in mon...
DNA, Viral/genetics,
HIV-1,
DNA, Viral/chemistry,
Mozambique,
Drug Resistance, Viral,
Genetic Variation,
HIV Infections/virology,
HIV Integrase/genetics,
Molecular Sequence Data,
Mutation,
Proviruses/genetics,
Sequence Analysis, DNA
Vaz, paula;
Eugenia, macassa;
Jani, ilesh, v;
Thome, beatriz;
Mahagaja, epifanio;
Madede, tavares;
Muando, valeria;
Biberfeld, gunnel;
Anderson, soren;
Blanche, stephane.
AIDS-associated Kaposi sarcoma occurs in children, but treatment experience reports are very scarce. A retrospective analysis of 28 children treated with highly active antiretroviral therapy and monthly paclitaxel showed unexpected results with 19 children in complete and sustainable remission, including...
Anti-Retroviral Agents/administration & dosage,
Antineoplastic Agents/administration & dosage,
Antiretroviral Therapy, Highly Active/methods,
Drug Therapy/methods,
HIV Infections/complications,
HIV Infections/virology,
HIV-1/isolation & purification,
Sarcoma, Kaposi/therapy,
Sarcoma, Kaposi/pathology,
Treatment Outcome
To determine the prevalence of acute HIV infection (AHI) within the HIV-seronegative adult population presenting with reported fever in a district hospital in southern Mozambique and evaluate clinical, immunological and virological parameters of AHI.
Design:
This is a prospective observational study.
...
HIV Infections/epidemiology,
Mozambique,
Outpatients,
HIV Infections/diagnosis,
d0084030,
HIV Seronegativity,
HIV-1/immunology,
Malaria, Falciparum/diagnosis,
Malaria, Falciparum/epidemiology,
Plasmodium falciparum/isolation & purification
Células Treg sao elementos fundamentais na manutenção da homeostasia ao nível do
sistema imunolodégico. Defeitos nestas células tém sido implicados no desenvolvimento de
varias imunopatologias de origem autoimune ou infecciosa, incluindo aquelas que ocorrem
ao nivel dos órgãos imunoprivilegiados...
Vaz, paula;
Chaix, marie-laure;
Jani, ilesh;
Macassa, eugenia;
Bila, Dulce;
Vubil, Adolfo;
Anderson, Soren;
Rouzioux, christine, pharmD;
Briand, nelly;
Blanche, stephane.
Background: Resistant virus may be selected by sub-optimal control of HIV-1 replication during antiretroviral treatment. The incidence and profile of resistance in children receiving World Health Organization-recommended treatment remains to be evaluated on a large scale.
Goals: Assessment of the frequen...
Drug Resistance,
HIV-1/genetics,
Anti-HIV Agents,
HIV Infections/blood,
Virus Replication,
Analysis of Variance,
HIV-1/physiology,
HIV Infections/therapy,
HIV Infections/virology,
Reverse Transcriptase Inhibitors/pharmacology,
Reverse Transcriptase Inhibitors/therapeutic use,
Anti-HIV Agents/pharmacology,
Anti-HIV Agents/therapeutic use,
Treatment Failure,
Mozambique
