Aguilar, Ruth;
Tejada, Ariel Magallon;
Achtman, Ariel H;
Moraleda, Cinta;
Joice, Regina;
Cisteró, Pau;
Suen, Connie S. N. Li Wai;
Nhabomba, Augusto;
Macete, Eusebio;
Mueller, Ivo;
Marti, Matthias;
Alonso, Pedro L;
Menéndez, Clara;
Schofield, Louis;
Mayor, Alfredo.
Plasmodium falciparum immature gametocytes are not observed in peripheral blood. However, gametocyte stages in organs such as bone marrow have never been assessed by molecular techniques, which are more sensitive than optical microscopy. We quantified P falciparum sexual stages in bone marrow (n = 174) a...
Anemia/parasitology,
Anemia/genetics,
Bone Marrow/pathology,
Bone Marrow/parasitology,
DNA, Protozoan/analysis,
Life Cycle Stages/genetics,
Malaria, Falciparum/diagnosis,
Malaria, Falciparum/genetics,
Malaria, Falciparum/parasitology,
Molecular Diagnostic Techniques,
Plasmodium falciparum/genetics,
Plasmodium falciparum/growth & development,
Plasmodium falciparum/isolation & purification,
Polymerase Chain Reaction,
Mozambique
Background: Asymptomatic Plasmodium falciparum parasitemia (APFP) has been reported to be highly prevalent in Sub-Saharan Africa, a region heavily burdened by malaria, yet, the impact of APFP on the immunological reference values have not yet been established. This study was aimed at i) determine the pre...
A malária e HIV/SIDA representam os dois principais problemas de saúde pública no mundo. O efeito da imunodepressão causada pelo HIV/SIDA afecta a resposta imune do hospedeiro contra a malária; contudo estudos sobre o impactodo HIV/SIDA na resposta humoral contra Pl...
Malaria/prevention & control,
Malaria/complications,
Malaria/drug therapy,
Immunity, Humoral/immunology,
Antigens/administration & dosage,
Malaria, Falciparum/drug therapy,
Sexually Transmitted Diseases/transmission,
HIV,
Patients,
Morbidity/trends,
Mortality/trends
Human immunodeficiency virus (HIV)-1 infection has an important impact on malaria. Plasmodium falciparum
and HIV-1 co-infected patients (Pf/HIV) present with a high degree of anaemia, enhanced parasitaemia and decreased
CD4+ T cell counts, which increase the risk of developing severe malaria. In addition...
Background: Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual.
Methods: A cross-sectional study among HIV-1 infected and uninfected populations...
Quelhas, Diana;
Puyol, Laura;
Quinto, Llorenç;
Nhsmpossa, Tacilta;
Casas, Elisa Serra;
Macete, Eusébio;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Doolan, Denise L;
Menendez, Clara;
Dobano, Carlota.
Cytokines and chemokines are key mediators of anti-malarial immunity. We evaluated whether Intermittent Preventive Treatment in infants with Sulfadoxine-Pyrimethamine (IPTi-SP) had an effect on the acquisition of these cellular immune responses in Mozambican children. Multiple cytokines and chemokines we...
Quelhas, diana;
Puyol, Laura;
Quintó, llorenç;
Nhampassa, tacilta;
Cases, elisa serra;
Macete, eusébio;
Sanz, sergi;
Aponte, johs j;
Alonso, pedro;
Menéndez, clara;
Dobaño, carlota;
Doohan, denise.
Cytokines and chemokines are key mediators of anti-malarial immunity. We evaluated whether Intermittent Preventive Treatment in infants with Sulfadoxine-Pyrimethamine (IPTi-SP) had an effect on the acquisition of these cellular immune responses in Mozambican children. Multiple cytokines and chemokines we...
d0162070,
d0117390,
d0109490,
d0109630,
d0189250,
d0134130,
d0138120,
Antimalarials/therapeutic use,
Antimalarials/pharmacology,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control
Campos, josé j;
Dobaño, carlota;
Sacarlal, jahit;
Prefeito, alfredo;
Angov, evelina;
Dutta, shutij;
Chitnis, chetan;
Machete, eusébio;
Aponte, Joao j;
Alonso, pedro l.
Partial protective efficacy lasting up to 43 months after vaccination with the RTS,S malaria vaccine has been reported in one cohort (C1) of a Phase IIb trial in Mozambique, but waning efficacy was observed in a smaller contemporaneous cohort (C2). We hypothesized that low dose exposure to asexual stage ...
Quelhas, Diana;
Jimenez, Alfons;
Quito, Llorenç;
Casas, Elisa Serra;
Mayor, Alfredo a d;
Cistero, Pau;
Puyol, Laura;
Wilson, Danny W. e;
Richards, Jack S;
Nhampossa, Tacilta;
Macete, Eusebioa;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Alonso, Pedro L;
Beeson, James G;
Menendez, Clara;
Dobano, Carlota.
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assesse...
Antibodies, Protozoan,
d0109630,
Antibodies, Protozoan/blood,
Antibody Formation/radiation effects,
Antigens, Protozoan/immunology,
Antigens, Surface/immunology,
Antineoplastic Combined Chemotherapy Protocols/chemistry,
Immunoglobulin G/blood,
Malaria, Falciparum/blood,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Membrane Proteins/immunology,
Plasmodium falciparum/immunology,
Plasmodium falciparum/pathogenicity,
Protozoan Proteins/immunology,
Mozambique
Gillet, philippe;
Annelies, Scheirlinck;
Stokx, jocelijn;
Weggheleire, anja de;
Chaúque, hélder s;
Canhanga, oreana D J V;
Tadeu, benvindo t;
Mosse, carla d d;
Tiago, armindo;
Mabunda, Samuel;
Bruggeman, cathrien;
Bottieau, emmanuel;
Jacobs, jan.
Background: Prozone means false-negative or false-low results in antigen-antibody reactions, due to an excess of either antigen or antibody. The present study prospectively assessed its frequency for malaria rapid diagnostic tests (RDTs) and Plasmodium falciparum samples in an endemic field setting.
Met...
