Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Sharp, brian l;
Kleinschmidt, immo;
Streat, elisabeth;
Maharaj, rajendra;
Barnes, karen i;
Durrheim, david n;
Ridl, frances c;
Morris, natasha;
Seocharan, ishen;
Kunene, simon;
Grange, jacobus j p la;
Mthembu, jotham d;
Maartens, francois;
Martin, carrin l;
Barreto, avertino.
International Cooperation,
Insect Vectors,
Eswatini/epidemiology,
Child, Preschool,
Antimalarials/therapeutic use,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Mosquito Control/methods,
Mozambique/epidemiology,
Plasmodium falciparum/isolation & purification,
Prevalence,
South Africa/epidemiology,
Time Factors
Objective: To describe attitudes to the expanded programme on immunization (EPI) and intermittent preventive treatment in infants (IPTi), and perceptions of the relationship between them. In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conver...
Health Knowledge, Attitudes, Practice,
Caregivers/psychology,
Delivery of Health Care/methods,
Delivery of Health Care/organization & administration,
Hematologic Tests/psychology,
Immunization/psychology,
Malaria Vaccines/therapeutic use,
Immunization Programs/organization & administration,
Malaria, Falciparum/psychology,
Patient Acceptance of Health Care/psychology,
Mozambique/epidemiology
Enosse, Sonia;
Dobaño, Carlota;
Quelhas, Diana;
Aponte, John J;
Lievens, Marc;
Leach, Amanda;
Sacarlal, Jahit;
Greenwood, Brian;
Milman, Jessica;
Dubovsky, Filip;
Cohen, Joe;
Thompson, Ricardo;
Ballou, W Ripley;
Alonso, Pedro L;
Conway, David J;
Sutherland, Colin J.
The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite protein (CSP) sequence of Plasmodium falciparum, linked to the hepatitis B surface antigen and formulated in the proprietary adjuvant system AS02A. In a recent trial conducted in children younger th...
Malaria,
T-Lymphocytes/immunology,
Parasites/parasitology,
Cells,
Malaria, Falciparum/diagnosis,
Malaria Vaccines/immunology,
Protozoan Infections/transmission,
Malaria, Falciparum/transmission,
Malaria, Falciparum/prevention & control,
Mozambique
We compared the distribution patterns of individual Plasmodium species and mixed-species infections in two geographically close endemic areas, but showing environmental differences. Comparisons concerned circulating Plasmodium infections in both human and mosquito vector populations in the dry and wet se...
Malaria/epidemiology,
Malaria/parasitology,
Mozambique,
Species Specificity,
Plasmodium ovale,
Coinfection,
Malaria, Falciparum/diagnosis,
Coinfection/transmission,
Plasmodium falciparum/isolation & purification,
Plasmodium ovale/isolation & purification,
Polymerase Chain Reaction,
Mozambique/epidemiology
Alonso, pedro L;
Sacarlal, jahit;
Aponte, john J;
Leach, amanda;
Macete, eusebio;
Milman, jessica;
Mandomando, inacio;
Spiessens, Bart;
Guinovart, caterina;
Espasa, mateu;
Bassat, quique;
Aide, pedro;
Anyinam, opokua Ofori;
Navia, margarita M;
Corachan, sabine.
Background: Development of an effective malaria vaccine could greatly contribute to disease control. RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. We aimed to assess vaccine efficacy, immunogenicity, and safety in young African childr...
Abacassamo, F;
Enosse, S;
Aponte, J J;
Go ́mez-Olive, ́FX;
Quinto ́, L;
Mabunda, S;
Barreto, A;
Magnussen, P;
Rønn, A M;
Thompson, R;
Alonso, P L.
This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomp...
Chloroquine/adverse effects,
Amodiaquine/administration & dosage,
Malaria, Falciparum/drug therapy,
Sulfadoxine/administration & dosage,
Antimalarials/administration & dosage,
Antimalarials/adverse effects,
Chloroquine/administration & dosage,
Malaria, Falciparum/therapy,
Plasmodium falciparum/radiation effects,
Pyrimethamine/administration & dosage,
Pyrimethamine/adverse effects,
Treatment Outcome
We estimated the incidence of clinical malaria episodes by weekly home-based active case detection between December 1996 and July 1999 in 2 groups of children in Manhiça district in southern Mozambique. Cohort 1 comprised a random sample of children aged <10 years at recruitment and cohort 2 comprised n...
A total of 2057 children aged <10 years were selected at random from a demographic surveillance system and enrolled in 4 malariometric cross-sectional surveys in different seasons in Manhiça district in southern Mozambique. Plasmodium falciparum accounted for 90% of all malaria infections and the preval...
