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Validity of reported retention in antiretroviral therapy after roll-out to peripheral facilities in Mozambique: Results of a retrospective national cohort analysis

Lafort, yves; Couto, aleny; Sunderbrink, ute; Hoek, roxanne; Shargie, Estifanos; Zhao, Jinkou; Viisainen, kirsi; Simwaka, bertha.
PLOS ONE; 13 (6), 2018
Retention in anti-retroviral therapy (ART) presents a challenge in sub-Saharan Africa. In Mozambique, after roll-out to peripheral facilities, the 12-month retention rate was reported mostly from sites with an electronic patient tracking system (EPTS), representing only 65% of patients. We conducted a na...
Anti-HIV Agents/pharmacology, CD4 Lymphocyte Count, Death, Lost to Follow-Up, Patient Identification Systems, HIV, Adolescent, Mozambique/epidemiology, HIV Testing, Anti-Retroviral Agents/therapeutic use, HIV/drug effects, Pregnancy
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Evolution of primary HIV drug resistance in a subtype C dominated epidemic in Mozambique

Bila, Dulce Celina Adolfo; Young, Pedro; Merks, Harriet; Vubil, Adolfo Salvador; Mahomed, Mussagy; Augusto, Angelo; Abreu, Celina Monteiro; Mabunda, Nédio Jonas; Brooks, James, I; Tanuri, Amilcar; Jani, Ilesh Vinodrai.
PLos ONE; 7 (9), 2012
Objective: InMozambique, highly active antiretroviral treatment (HAART) was introduced in 2004 followed by decentralizationandexpansion, resulting inamorethan20-fold increase incoverageby2009. ImplementationofHIV drugresistancethresholdsurveys (HIVDR-TS) iscrucial inorder tomonitor theemergenceof transmi...
Anti-HIV Agents/pharmacology, Anti-HIV Agents/therapeutic use, Antiretroviral Therapy, Highly Active, Mozambique, Drug Resistance, Viral/genetics, HIV Infections/therapy, HIV Infections/epidemiology, HIV Infections/virology, HIV-1/classification, HIV-1/radiation effects, HIV-1/genetics, Mozambique/epidemiology, Mutation, Phylogeny
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Risk of extended viral resistance in human immunodeficiency virus-1-infected Mozambican children after first-line treatment failure

Vaz, paula; Chaix, marie-laure; Jani, ilesh; Macassa, eugenia; Bila, Dulce; Vubil, Adolfo; Anderson, Soren; Rouzioux, christine, pharmD; Briand, nelly; Blanche, stephane.
Pediatr. infect. dis. j; 28 (12), 2009
Background: Resistant virus may be selected by sub-optimal control of HIV-1 replication during antiretroviral treatment. The incidence and profile of resistance in children receiving World Health Organization-recommended treatment remains to be evaluated on a large scale. Goals: Assessment of the frequen...
Drug Resistance, HIV-1/genetics, Anti-HIV Agents, HIV Infections/blood, Virus Replication, Analysis of Variance, HIV-1/physiology, HIV Infections/therapy, HIV Infections/virology, Reverse Transcriptase Inhibitors/pharmacology, Reverse Transcriptase Inhibitors/therapeutic use, Anti-HIV Agents/pharmacology, Anti-HIV Agents/therapeutic use, Treatment Failure, Mozambique
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Molecular Epidemiology and Trends in HIV-1 Transmitted Drug Resistance in Mozambique 1999–2018

Ismael, Nalia; Wilkinson, Eduan; Mahumane, Isabel; Mahumane, Isabel; Gemusse, Hernanane; Giandhari, Jennifer; Bauhofer, Adilson; Vubil, Adolfo; Mambo, Pirolita; Singh, Lavanya; Mabunda, Nédio; Bila, Dulce; Engelbrecht, Susan; Gudo, Eduardo; Lessells, Richard; Oliveira, Túlio.
Viruses; 14 (9), 1992
HIV drug resistance (HIVDR) can become a public health concern, especially in low- and middle-income countries where genotypic testing for people initiating antiretroviral therapy (ART) is not available. For first-line regimens to remain effective, levels of transmitted drug resistance (TDR) need to be m...
Mozambique/epidemiology, HIV-1/genetics, Drug Resistance, Viral/genetics, Anti-HIV Agents/therapeutic use, Anti-HIV Agents/pharmacology, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Seropositivity, Molecular Epidemiology, Reverse Transcriptase Inhibitors/pharmacology, Prevalence
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