Toxoplasmosis is a parasitic zoonotic disease caused by Toxoplasma gondii that afflicts humans worldwide and wild and domestic warm-blooded animals. In immunocompetent individuals, the acute phase of infection presents transient low or mild symptoms that remain unnoticed. In immunocompromised patients, T...
Antibodies, Protozoan/blood,
Biomedical Research/trends,
Immunocompromised Host,
Pregnancy Complications, Parasitic/epidemiology,
Toxoplasma/genetics,
Immunoglobulin G/blood,
Zoonoses/epidemiology,
Risk Factors,
Mozambique/epidemiology,
Toxoplasma/pathogenicity,
Toxoplasmosis/complications,
Toxoplasmosis/epidemiology,
Toxoplasmosis, Congenital/epidemiology
Ubillos, itziar;
Kurtovic, liriye;
Agius, paulo, a;
Feng, gaoqian;
Drew, damien, r;
Sacarlal, jahit;
Aponte, john, j;
Fowkes, freya, j;
Dobaño, carlota;
Beeson, james, g.
Background: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S
confers partial protection against malaria in children, but efficacy wanes relatively quickly after primary
immunization. Vaccine efficacy has some association with anti-CSP IgG; however, it i...
Valmaseda, aida;
Macete, eusebio;
Nhabomba, augusto;
Guinovart, caterina;
Aide, pedro;
Bardají, azucena;
Bassat, quique;
Nhampossa, tacilta;
Maculuve, sonia;
Casellas, aina;
Quintó, llorenç;
Sanz, sergi;
Jiménez, alfons;
Feng, gaoqian;
Langer, christine;
Reiling, linda;
Reddy, k, sony;
Pandey, alok;
Chitnis, chetan, e;
Chauhan, virander, s;
Aguilar, ruth;
Aponte, john, j;
Dobaño, carlota;
Beeson, james, g;
Gaur, deepak;
Menéndez, clara;
Alonso, pedro, l;
Mayor, alfredo.
Background: A main criterion to identify malaria vaccine candidates is the proof that acquired immunity against them is associated with protection from disease. The age of the studied individuals, heterogeneous malaria exposure, and assumption of the maintenance of a baseline immune response can confound...
Adaptive Immunity,
Age Factors,
Antibodies, Protozoan/immunology,
Antigens, Protozoan/immunology,
Immunoglobulin G/immunology,
Immunoglobulin M/immunology,
Malaria Vaccines/immunology,
Malaria, Falciparum/prevention & control,
Plasmodium falciparum,
Mozambique
Fonseca, ana maria;
Quinto, llorenç;
Jiménez, alfons;
González, raquel;
Bardají, azucena;
Maculuve, sonia;
Dobaño, carlota;
Rupérez, maria;
Vala, anifa;
Aponte, john, j;
Sevene, esperanza;
Macete, Eusebio;
Menéndez, clara;
Mayor, alfredo.
Background: Pregnant women exposed to Plasmodium falciparum generate antibodies against VAR2CSA, the parasite protein that mediates adhesion of infected erythrocytes to the placenta. There is a need of high-throughput tools to determine the fine specificity of these antibodies that can be used to identif...
Antibodies, Protozoan/blood,
Antibodies, Protozoan/immunology,
Antigens, Protozoan/genetics,
Antigens, Protozoan/immunology,
Antigens, Protozoan/metabolism,
Dried Blood Spot Testing,
Erythrocytes/parasitology,
Immunoassay,
Immunoglobulin G/blood,
Malaria, Falciparum/diagnosis,
Plasmodium falciparum/isolation & purification,
Pregnancy
Mayor, Alfredo;
Bardají, Azucena;
Macete, Eusebio;
Nhampossa, Tacilta;
Fonseca, Ana Maria;
González, Raquel;
Maculuve, Sonia;
Cisteró, Pau;
Rupérez, Maria;
Campo, Joe;
Vala, Anifa;
Sigaúque, Betuel;
Jiménez, Alfons;
Machevo, Sonia;
Fuente, Laura de la;
Nhama, Abel;
Luis, Leopoldina;
Aponte, John J;
Acácio, Sozinho;
Nhacolo, Arsenio;
Chitnis, Chetan;
Dobaño, Carlota;
Sevene, Esperanza;
Alonso, Pedro Luis;
Menéndez, Clara.
Background: Prevention of reinfection and resurgence is an integral component of the goal to eradicate malaria. However, the adverse effects of malaria resurgences are not known.
Methods: We assessed the prevalence of Plasmodium falciparum infection among 1819 Mozambican women who delivered infants betwe...
Antibodies, Protozoan/blood,
Immunoglobulin G/blood,
Malaria, Falciparum/classification,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/immunology,
Mozambique/epidemiology,
Parasite Load,
Parity,
Plasmodium falciparum/immunology,
Plasmodium falciparum/isolation & purification,
Pregnancy Complications, Infectious/classification,
Pregnancy Complications, Infectious/epidemiology,
Pregnancy Complications, Infectious/immunology,
Severity of Illness Index
A primary concern for the RTS,S malaria vaccine candidate is duration of protection. The ongoing Phase III trial reported evidence of waning efficacy within the first year following vaccination. Multiple Phase IIb trials demonstrated early waning of efficacy. The longest duration of protection for RTS,S ...
Immunoglobulin G/blood,
Antibodies, Protozoan/blood,
Malaria Vaccines/immunology,
Malaria Vaccines/therapeutic use,
Mozambique,
Malaria, Falciparum/prevention & control,
Parasitemia/prevention & control,
Randomized Controlled Trials as Topic,
Plasmodium falciparum
Quelhas, Diana;
Jimenez, Alfons;
Quito, Llorenç;
Casas, Elisa Serra;
Mayor, Alfredo a d;
Cistero, Pau;
Puyol, Laura;
Wilson, Danny W. e;
Richards, Jack S;
Nhampossa, Tacilta;
Macete, Eusebioa;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Alonso, Pedro L;
Beeson, James G;
Menendez, Clara;
Dobano, Carlota.
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assesse...
Antibodies, Protozoan,
d0109630,
Antibodies, Protozoan/blood,
Antibody Formation/radiation effects,
Antigens, Protozoan/immunology,
Antigens, Surface/immunology,
Antineoplastic Combined Chemotherapy Protocols/chemistry,
Immunoglobulin G/blood,
Malaria, Falciparum/blood,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Membrane Proteins/immunology,
Plasmodium falciparum/immunology,
Plasmodium falciparum/pathogenicity,
Protozoan Proteins/immunology,
Mozambique
Quelhas, diana;
Casas, elisa serra;
Quinto, llorenç;
Puyol, laura;
Nhampossa, tacilta;
Macete, eusebio;
Aide, pedro;
Mayor, alfredo;
Mandomando, inacio;
Sanz, sergio;
Aponte, john J;
Chitnis, chetan E;
Chauhan, virander S;
Alonso, pedro L;
Dobano, carlota;
Menendez, clara.
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunization (EPI), on the development of antibody responses to Plasmodium falciparum in Mozambique. Immunoglobuli...
Antibodies, Protozoan/blood,
Antibodies, Protozoan/immunology,
Antibodies, Protozoan/genetics,
Antimalarials/administration & dosage,
Antimalarials/therapeutic use,
Malaria, Falciparum/immunology,
Malaria, Falciparum/prevention & control,
Plasmodium falciparum/immunology,
Pyrimethamine/administration & dosage,
Mozambique,
Recombinant Proteins/genetics,
Recombinant Proteins/immunology
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
