Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial
BMJ Open; 13 (10), 2023
Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquin...
Malaria, Falciparum/therapy, Artemisinins/radiation effects, Artemether, Lumefantrine Drug Combination, Randomized Controlled Trials as Topic, Pregnant Women, Infection Control, Parasitology, Sub-Saharan African People, Artemether/therapeutic use, Antimalarials/radiation effects, Mozambique/epidemiology