González, Raquel;
Nhampossa, Tacilta;
Mombo-Ngoma, Ghyslain;
Mischlinger, Johannes;
Esen, Meral;
Tchouatieu, André-Marie;
Mendes, Anete;
Figueroa-Romero, Antía;
Zoleko-Manego, Rella;
Lell, Bertrand;
Lagler, Heimo;
Stoeger, Linda;
Dimessa, Lia Betty;
El Gaaloul, Myriam;
Sanz, Sergi;
Méndez, Susana;
Piqueras, Mireia;
Sevene, Esperança;
Ramharter, Michael;
Saúte, Francisco;
Menendez, Clara.
For this randomised, double-blind, placebo-controlled clinical trial, women with HIV attending the first antenatal care clinic visit, resident in the study area, and with a gestational age up to 28 weeks were enrolled at five sites in Gabon and Mozambique. Participants were randomly assigned (1:1) to rec...
Antimalarials/administration & dosage,
Artemisinins/administration & dosage,
Double-Blind Method,
Drug Combinations,
Gabon,
HIV Infections/complications,
Malaria/therapy,
Malaria/prevention & control,
Piperazines,
Pregnancy Complications,
Quinolines/administration & dosage,
Treatment Outcome,
Trimethoprim, Sulfamethoxazole Drug Combination,
Antimalarials/therapeutic use,
Antimalarials/adverse effects,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Mozambique/epidemiology,
Pregnancy Complications, Infectious/therapy,
Pregnancy Complications, Infectious/prevention & control
Matambisso, Glória;
Brokhattingen, Nanna;
Maculuve, Sónia;
Cístero, Pau;
Mbeve, Henriques;
Escoda, Anna;
Bambo, Gizela;
Cuna, Boaventura;
Melembe, Cardoso;
Ndimande, Nelo;
Tetteh, Kevin K. A;
Drakeley, Chris;
Gamain, Benoit;
Chitnis, Chetan;
Chauhan, Virander;
Quintó, Llorenç;
Macete, Eusébio;
Mayor, Alfredo.
Objective: The effectiveness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is threatened by increasing SP-resistance in Africa. We assessed the level of SP-resistance markers, and the clinical and parasitological effectiveness of IPTp-SP in southern...
Pyrimethamine,
Malaria, Falciparum,
Drug Resistance,
Chemoprevention/methods,
Antimalarials/therapeutic use,
Sulfadoxine,
Antineoplastic Combined Chemotherapy Protocols,
Pregnancy Complications, Parasitic/therapy,
Pregnancy Complications, Parasitic/prevention & control,
Mozambique/epidemiology
Cuinhane, Carlos Eduardo;
Galatas, Beatriz;
Lopez, Julia Montaña;
Djive, Helder;
Nhantumbo, Hoticha;
Murato, Ilda;
Saúte, Francisco;
Aide, Pedro;
Munguambe, Khátia;
Torres, Neusa.
This study analysed acceptability and perceived barriers to reactive focal mass drug administration (rfMDA) among community members exposed to community engagement campaigns and malaria elimination interventions in Magude district, following mass drug administration (MDA) in the same district. The study ...
Nhama , Abel;
Nhamússua, Lídia;
Macete, Eusébio;
Bassat, Quique;
Salvador, Crizolgo;
Enosse, Sónia;
Candrinho, Baltazar;
Carvalho, Eva;
Nhacolo, Arsénio;
Chidimatembue, Arlindo;
Saifodine , Abuchahama;
Zulliger, Rose;
Lucchi, Naomi;
Svigel, Samaly S;
Moriarty , Leah F;
Halsey, Eric S;
Mayor, Alfredo;
Aide , Pedro.
Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy...
Amodiaquine,
Antimalarials/therapeutic use,
Drug Combinations,
Antimalarials/standards,
Parasitemia,
Treatment Outcome,
d0082880,
Artemether, Lumefantrine Drug Combination/pharmacology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Malaria, Falciparum/therapy,
Parasitemia/drug therapy,
Mozambique/epidemiology
Mayor, Alfredo;
Silva, Clemente;
Valbona, Eduard Rovira;
Feltrer, Arantxa Roca;
Bonnington, Craig;
Smith, Alexandra Wharton;
Greehouse, Bryan;
Bever, Caitlin;
Chidimatembue, Arlindo;
Guinovart, Caterina;
Proctor, Joshua L;
Rodrigues, Maria;
Canana, Neide;
Arnaldo, Paulo;
Boene, Simone;
Enosse, Sonia;
Saute, Francisco;
Candrinho, Baltazar.
Introduction: Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions to reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims to operationalise a functional malaria molecular surveillance system in Moz...
Background: To improve the coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) in Africa, Medicines for Malaria Venture (MMV) developed, tested and validated a new packaging of sulfadoxine-pyrimethamine (SP), as well as specific communications tools designed to improve knowledge ...
Background: Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaq...
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Drug Resistance/genetics,
Drug Therapy, Combination,
Genetic Markers,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/genetics,
Plasmodium falciparum/isolation & purification,
Polymorphism, Genetic/genetics,
Mozambique
Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimalarials/administration & dosage,
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/administration & dosage,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Antineoplastic Combined Chemotherapy Protocols,
Drug Resistance/genetics,
Malaria/parasitology,
Malaria/prevention & control,
Mozambique,
Plasmodium falciparum/immunology,
Plasmodium falciparum/genetics,
Plasmodium falciparum/pathogenicity,
Polymorphism, Genetic,
Protozoan Proteins/genetics,
Protozoan Proteins/metabolism,
Quinolines/administration & dosage,
Quinolines/therapeutic use,
Quinolines/pharmacology
Huijben, silvie;
Macete, eusebio;
Ngoma, ghyslain mombo;
Ramharter, michael;
Kariuki, Simon;
Desai, meghna;
Shi, ya ping;
Uberegui, estefania;
Mwangoka, grace;
Massougbodji, achille;
Cot, michel;
Ndam, nicaise tuikue;
Gupta, himanshu;
Cisteró, pau;
Aponte, john, j;
González, raquel;
Menéndez, clara;
Mayor, alfredo.
Background: Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions.
Methods: Plasmod...
Antimalarials/therapeutic use,
Drug Combinations,
Drug Resistance, Multiple/drug effects,
Malaria, Falciparum/blood,
Mefloquine/therapeutic use,
Polymorphism, Genetic,
Malaria, Falciparum/drug therapy,
Malaria/epidemiology
Candrinho, Baltazar;
Plucinski, Mateusz M;
Colborn, James M;
Mathe, Guidion;
Silva, Mariana da;
Dimene, Mercia;
Chico, Ana Rita;
Branco, Ana Christina Castel;
Brito, Frederico;
Andela, Marcel;
Leon, Gabriel Ponce de;
Saifodine, Abuchahama;
Zulliger, Rose.
Background: Fever associated with malaria is the leading cause of health care-seeking in Mozambique, yet there is limited evidence on the quality of malaria case management. This study evaluated the quality of malaria service provision offered in public health facilities in Mozambique.
Methods: A cross-s...
