Cuinhane, Carlos Eduardo;
Galatas, Beatriz;
Lopez, Julia Montaña;
Djive, Helder;
Nhantumbo, Hoticha;
Murato, Ilda;
Saúte, Francisco;
Aide, Pedro;
Munguambe, Khátia;
Torres, Neusa.
This study analysed acceptability and perceived barriers to reactive focal mass drug administration (rfMDA) among community members exposed to community engagement campaigns and malaria elimination interventions in Magude district, following mass drug administration (MDA) in the same district. The study ...
Nhama , Abel;
Nhamússua, Lídia;
Macete, Eusébio;
Bassat, Quique;
Salvador, Crizolgo;
Enosse, Sónia;
Candrinho, Baltazar;
Carvalho, Eva;
Nhacolo, Arsénio;
Chidimatembue, Arlindo;
Saifodine , Abuchahama;
Zulliger, Rose;
Lucchi, Naomi;
Svigel, Samaly S;
Moriarty , Leah F;
Halsey, Eric S;
Mayor, Alfredo;
Aide , Pedro.
Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy...
Amodiaquine,
Antimalarials/therapeutic use,
Drug Combinations,
Antimalarials/standards,
Parasitemia,
Treatment Outcome,
d0082880,
Artemether, Lumefantrine Drug Combination/pharmacology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Malaria, Falciparum/therapy,
Parasitemia/drug therapy,
Mozambique/epidemiology
Mayor, Alfredo;
Silva, Clemente;
Valbona, Eduard Rovira;
Feltrer, Arantxa Roca;
Bonnington, Craig;
Smith, Alexandra Wharton;
Greehouse, Bryan;
Bever, Caitlin;
Chidimatembue, Arlindo;
Guinovart, Caterina;
Proctor, Joshua L;
Rodrigues, Maria;
Canana, Neide;
Arnaldo, Paulo;
Boene, Simone;
Enosse, Sonia;
Saute, Francisco;
Candrinho, Baltazar.
Introduction: Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions to reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims to operationalise a functional malaria molecular surveillance system in Moz...
Background: Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaq...
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Drug Resistance/genetics,
Drug Therapy, Combination,
Genetic Markers,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/genetics,
Plasmodium falciparum/isolation & purification,
Polymorphism, Genetic/genetics,
Mozambique
Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimalarials/administration & dosage,
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/administration & dosage,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Antineoplastic Combined Chemotherapy Protocols,
Drug Resistance/genetics,
Malaria/parasitology,
Malaria/prevention & control,
Mozambique,
Plasmodium falciparum/immunology,
Plasmodium falciparum/genetics,
Plasmodium falciparum/pathogenicity,
Polymorphism, Genetic,
Protozoan Proteins/genetics,
Protozoan Proteins/metabolism,
Quinolines/administration & dosage,
Quinolines/therapeutic use,
Quinolines/pharmacology
Huijben, silvie;
Macete, eusebio;
Ngoma, ghyslain mombo;
Ramharter, michael;
Kariuki, Simon;
Desai, meghna;
Shi, ya ping;
Uberegui, estefania;
Mwangoka, grace;
Massougbodji, achille;
Cot, michel;
Ndam, nicaise tuikue;
Gupta, himanshu;
Cisteró, pau;
Aponte, john, j;
González, raquel;
Menéndez, clara;
Mayor, alfredo.
Background: Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions.
Methods: Plasmod...
Antimalarials/therapeutic use,
Drug Combinations,
Drug Resistance, Multiple/drug effects,
Malaria, Falciparum/blood,
Mefloquine/therapeutic use,
Polymorphism, Genetic,
Malaria, Falciparum/drug therapy,
Malaria/epidemiology
Arnaldo , Paulo;
Vallbona, Eduard Rovira;
Langa, Jerónimo S;
Salvador, Crizolgo;
Guetens, Pieter;
Chiheb, Driss;
Xavier , Bernardete;
Kestens, Luc;
Enosse, Sónia M;
Urgell , Anna Rosanas.
Malaria in pregnancy leads to serious adverse effects on the mother and the child and accounts for 75,000-200,000 infant deaths every year. Currently, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) at each sche...
Pyrimethamine/administration & dosage,
Sulfadoxine/administration & dosage,
Antimalarials/therapeutic use,
d0082880,
d0149300,
d0149440,
d0090350,
Antimalarials/administration & dosage,
Pharmaceutical Preparations,
Health Facilities,
Drug Combinations,
Labor, Obstetric/radiation effects,
Pregnancy Complications, Parasitic,
Mozambique,
Risk Factors,
Malaria/prevention & control
Salvador, Crizolgo;
Rafael, Bernardete;
Matsinhe, Francisco;
Matsinhe, Francisco;
Candrinho , Baltazar;
Muthemba , Rosália;
Carvalho, Eva;
Naueia, Eva;
Sacarlal, Jahit;
Namboze, Josephine;
Tiago , Armindo;
Warsame, Marian;
Enosse, Sónia.
he resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control. We assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL), the first-line treatment of uncomplicated P. falciparum malaria, in children under five years of age in Mozambique. We con...
Antimalarials/therapeutic use,
Artemisinins/therapeutic use,
Malaria/epidemiology,
d0109630,
d0200660,
d0161330,
Artemether, Lumefantrine Drug Combination,
Drug Combinations,
Ethanolamines/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/genetics,
Polymerase Chain Reaction,
Mozambique/epidemiology
Kovacs, stephanie d;
Eijk, anna maria van;
Sevene, esperanca;
Dellicour, stephanie;
Weiss, noel, s;
Emerson, scott;
Steketee, richard;
Kuile, feiko O. ter;
Stergachis, andy.
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy....
Abortion, Spontaneous,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Cohort Studies,
Malaria/drug therapy,
Pregnancy Complications, Parasitic/drug therapy,
Malaria
Adjei, aexander;
Bana, solomon narh;
Amu, alberta;
Kukula, vida;
Nagai, richard afedi;
Agyei, seth owusu;
Oduro, abraham;
Macete, Eusebio;
Abdulla, salim;
Halidou, tinto;
Sie, ali;
Osei, isaac;
Sevene, esperance;
Asante, kwaku-poku;
Mulokozi, abdunoor;
Compaore, guillaume;
Valea, innocent;
Adjuik, martin;
Baiden, rita;
Ogutu, Bernhards;
Binka, fred;
Gyapong, margaret.
Background: Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. However, little was known on its post-registration safety and effectiveness in sub-Saharan Africa. DHA-PQ provides a long post-treatment pro...
