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Emergence of bedaquiline-resistant tuberculosis and of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains with rpoB Ile491Phe mutation not detected by Xpert MTB/RIF in Mozambique: a retrospective observational study

Barilar, ivan; Fernando, Tatiana; Utpatel, christian; Abujate, cláudio; Madeira, Carla, M; José, benedita; Mutaquiha, claudia; Kranzer, katharina; Niemann, tanja.
Lancet, Infect. dis.; 12 (23), 2023
Background In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants o...
Antitubercular Agents/pharmacology, Antitubercular Agents/therapeutic use, Fluoroquinolones/pharmacology, Tuberculosis, Multidrug-Resistant, Mozambique, Mycobacterium tuberculosis/genetics, Rifampin/therapeutic use, Tuberculosis/therapy, Tuberculosis, Multidrug-Resistant/therapy
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Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing

Namburete, Evangelina Inácio; Tivane, Inês; Lisboa, Miguelhete; Passeri, Margarida; Pocente, Renata; Ferro, Josefo Joao; Harrison, Lee H; Bollela, Valdes Roberto.
BMC infect. dis; 16 (423), 2016
Background: Genotypic molecular testing may be very helpful for tuberculosis (TB) drug-resistance surveillance and for treatment guidance in low resource settings. Methods: Descriptive analysis of M. tuberculosis isolates from Beira Central Hospital, Mozambique, during 2014-2015. Genotype MTBDRplus and ...
Antitubercular Agents/therapeutic use, Antitubercular Agents/pharmacology, Drug Resistance, Bacterial/drug effects, Ethambutol/therapeutic use, Fluoroquinolones/therapeutic use, Microbial Sensitivity Tests, Tuberculosis, Pulmonary/microbiology, Mycobacterium tuberculosis/isolation & purification, Mozambique
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