Djimde, Moussa;
Tshiongo, Japhet Kabalu;
Muhindo, Hypolite Mavoko;
Tinto, Halidou;
Sevene, Esperança;
Traore, aminata;
Vala, Anifa;
Macuacua, Salesio;
Kabore, Berenger;
Dabira, Edgard Diniba;
Erhart, Annette;
Diakite, Hamadoun;
Keita, Mohamed;
Piqueras, Mireia;
González, Raquel;
Menendez, clara;
Dorlo, Thomas Pc;
Sagara, Issaka;
Mens, Petra;
Schallig, Henk;
D'Alessandro, Umberto;
Kayentao, Kassoum.
Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquin...
Malaria, Falciparum/therapy,
Artemisinins/radiation effects,
Artemether, Lumefantrine Drug Combination,
Randomized Controlled Trials as Topic,
Pregnant Women,
Infection Control,
Parasitology,
Sub-Saharan African People,
Artemether/therapeutic use,
Antimalarials/radiation effects,
Mozambique/epidemiology
Malaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is the world's fourth largest contributor, with 4.7% of disease cases and 3.6% of total deaths due to malaria. Its control relies on the fight against the vector and treatment of confirmed cases with anti-...
Background: The entire population of Mozambique is at risk for malaria, which remains one of the leading causes of death. The 2017-2022 National Malaria Strategic Plan focuses on reducing malaria morbidity and mortality in high- and low-transmission areas. This study aimed to estimate the costs and healt...
González, raquel;
Nhampossa, tacilta 3;
Ngoma, ghyslain mombo;
Mischlinger, johannes;
Esen, meral;
Tchouatieu, andré marie;
Duran, clara pons;
Dimessa, lia betty;
Lell, bertrand;
Lagler, heimo;
Otero, laura garcia.
Introduction: Malaria infection during pregnancy is an important driver of maternal and neonatal health especially among HIV-infected women. Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine is recommended for malaria prevention in HIV-uninfected women, but it is contr...
Antimalarials/adverse effects,
Artemisinins,
Artesunate/administration & dosage,
HIV Infections/prevention & control,
Infectious Disease Transmission, Vertical/prevention & control,
Malaria/prevention & control,
Mozambique/epidemiology,
Pregnancy Complications, Parasitic/chemically induced,
Pregnancy Complications, Parasitic/prevention & control,
Quinolines
Background: Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaq...
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Drug Resistance/genetics,
Drug Therapy, Combination,
Genetic Markers,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/genetics,
Plasmodium falciparum/isolation & purification,
Polymorphism, Genetic/genetics,
Mozambique
Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimalarials/administration & dosage,
Antimalarials/pharmacology,
Antimalarials/therapeutic use,
Artemisinins/administration & dosage,
Artemisinins/pharmacology,
Artemisinins/therapeutic use,
Antineoplastic Combined Chemotherapy Protocols,
Drug Resistance/genetics,
Malaria/parasitology,
Malaria/prevention & control,
Mozambique,
Plasmodium falciparum/immunology,
Plasmodium falciparum/genetics,
Plasmodium falciparum/pathogenicity,
Polymorphism, Genetic,
Protozoan Proteins/genetics,
Protozoan Proteins/metabolism,
Quinolines/administration & dosage,
Quinolines/therapeutic use,
Quinolines/pharmacology
Orvalho, Augusto;
Stergachis, Andy;
Dellicour, Stephanie;
Tinto, Halidou;
Valá, Anifa;
Ruperez, Maria;
Macete, Eusébio;
Nakanabo-Diallo, Seydou;
Kazienga, Adama;
Valéa, Innocent;
d'Alessandro, Umberto;
Kuile, Feiko O Ter;
S Calip, Gregory;
Ouma, peter;
Desai, Meghna;
Sevene, Esperança.
While there is increasing evidence on the safety of artemisinin-based combination therapy (ACT) for the case management of malaria in early pregnancy, little is known about the association between exposure to ACT during the first trimester and the effect on fetal growth. Data were analysed from prospecti...
Combined Modality Therapy,
Artemisinins,
Antimalarials,
Malaria,
Pregnancy,
Pregnancy Trimester, First,
Infant, Small for Gestational Age,
Infant, Low Birth Weight
Sevene, esperança;
Banda, clifford G;
Mukaka, mavuto;
Maculuve, sonia;
Vala, anifa;
Macuacua, salésio;
Piqueras, mireia;
Phiri, linda kalilani;
Mallewa, jane;
Terlouw, dianne J;
Khoo, saye H;
Lalloo, david G;
Mwapasa, victor.
Background: HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efcacy and safety has not been ...
Salvador, Crizolgo;
Rafael, Bernardete;
Matsinhe, Francisco;
Matsinhe, Francisco;
Candrinho , Baltazar;
Muthemba , Rosália;
Carvalho, Eva;
Naueia, Eva;
Sacarlal, Jahit;
Namboze, Josephine;
Tiago , Armindo;
Warsame, Marian;
Enosse, Sónia.
he resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control. We assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL), the first-line treatment of uncomplicated P. falciparum malaria, in children under five years of age in Mozambique. We con...
Antimalarials/therapeutic use,
Artemisinins/therapeutic use,
Malaria/epidemiology,
d0109630,
d0200660,
d0161330,
Artemether, Lumefantrine Drug Combination,
Drug Combinations,
Ethanolamines/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/genetics,
Polymerase Chain Reaction,
Mozambique/epidemiology
Kovacs, stephanie d;
Eijk, anna maria van;
Sevene, esperanca;
Dellicour, stephanie;
Weiss, noel, s;
Emerson, scott;
Steketee, richard;
Kuile, feiko O. ter;
Stergachis, andy.
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy....
Abortion, Spontaneous,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Cohort Studies,
Malaria/drug therapy,
Pregnancy Complications, Parasitic/drug therapy,
Malaria
