Carlucci, james;
Schacht, caroline de;
Graves, erin;
González, purificación;
Bravo, magdalena;
Yu , zhihong;
Amorim , gustavo;
Arinze, folasade;
Silva, wilson;
Tique, jose a;
Alvim, maria;
Simione, beatriz;
Fernando, anibal n;
Wester, c william.
Background: Historically, antiretroviral therapy (ART) initiation was based on CD4 criteria, but this has been replaced with "Test and Start" wherein all people living with HIV are offered ART. We describe the baseline immunologic status among children relative to evolving ART policies in Mozambique.
Me...
Background: There has been tremendous progress in the fight against HIV worldwide; however, challenges persist in the control of HIV infection. These challenges include the high prevalence of late presenters. There are many disadvantages of late presentation-from reduced survival of the infected person t...
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
AIDS Vaccines/immunology,
Antibodies, Neutralizing/immunology,
CD4 Lymphocyte Count,
Cytokines/biosynthesis,
HIV Antibodies/immunology,
HIV Infections/prevention & control,
HIV Infections/virology,
HIV-1/immunology,
HIV-1/genetics,
Mozambique,
CD8-Positive T-Lymphocytes/immunology,
T-Lymphocytes, Regulatory/metabolism,
Vaccines, DNA/immunology,
Vaccines, DNA/genetics
Retention in anti-retroviral therapy (ART) presents a challenge in sub-Saharan Africa. In
Mozambique, after roll-out to peripheral facilities, the 12-month retention rate was reported
mostly from sites with an electronic patient tracking system (EPTS), representing only 65%
of patients. We conducted a na...
Anti-HIV Agents/pharmacology,
CD4 Lymphocyte Count,
Death,
Lost to Follow-Up,
Patient Identification Systems,
HIV,
Adolescent,
Mozambique/epidemiology,
HIV Testing,
Anti-Retroviral Agents/therapeutic use,
HIV/drug effects,
Pregnancy
Marotta, Claudia;
Giaquinto, Carlo;
i Gennaro, Francesco;
Chhaganlal, Kajal D;
Saracino, Annalisa;
Moiane, Jorge;
aringhini, Guido;
Pizzol, Damiano;
Putoto, Giovanni;
Monno, Laura;
Casuccio, Alessandra;
Vitale, Francesco;
Mazzucco, Walter.
Background: In 2013, Mozambique implemented task-shifting (TS) from clinical officers to maternal and child
nurses to improve care for HIV positive children < 5 years old. A retrospective, pre-post intervention study was
designed to evaluate effectiveness of a new pathway of care in a sample of Beira Dis...
Rupérez, María;
Julian, Marc Noguera;
González, Raquel;
Maculuve, Sonia;
Bellido, Rocío;
Vala, Anifa;
Rodríguez, Cristina;
Sevene, Esperança;
Paredes, Roger;
Menéndez, Clara.
Background: Few data on HIV resistance in pregnancy are available from Mozambique, one of the countries with the highest HIV toll worldwide. Understanding the patterns of HIV drug resistance in pregnant women might help in tailoring optimal regimens for prevention of mother to child transmission of HIV (...
Anti-HIV Agents/administration & dosage,
CD4 Lymphocyte Count/methods,
Drug Resistance, Viral,
HIV Infections/drug therapy,
Drug Resistance, Viral/drug effects,
Infectious Disease Transmission, Vertical/prevention & control,
Pregnancy Complications, Infectious/drug therapy,
Mozambique,
Prenatal Care/methods,
HIV-1/chemistry
A contagem dos Linfócitos TCD4+ no sangue periférico continua a ser um importante marcador para monitorar a progressão da doença e eficácia da terapia anti-retroviral (ART), apesar da introdução recentemente da testagem de carga viral, por ser um indicador mais sensível que a contagem de CD4; e c...
Background In resource-limited countries, CD4 T-cell (CD4) testing continues to be used for determining antiretroviral therapy (ART) initiation eligibility and opportunistic infection monitoring. To support expanded access to CD4 testing, simple and robust technologies are necessary. We conducted this st...
Sensitivity and Specificity,
Reproducibility of Results,
Mozambique,
Middle Aged,
Men,
Humans,
HIV Seropositivity,
Allergy and Immunology,
Child, Preschool,
CD4 Lymphocyte Count/instrumentation,
HIV Infections/immunology
Schacht, Caroline De;
Lucas, Carlota;
Sitoe, Nádia;
Machekano, Rhoderick;
Chongo, Patrina;
Temmerman, Marleen;
Tobaiwa, Ocean;
Guay, Laura;
Kassaye, Seble;
Jani, Ilesh V.
Introduction: Anemia, syphilis and HIV are high burden diseases among pregnant women in sub-Saharan Africa. A quasi-experimental study was conducted in four health facilities in Southern Mozambique to evaluate the effect of point-of-care technologies for hemoglobin quantification, syphilis testing and CD...
Anemia/diagnosis,
Anti-Retroviral Agents,
CD4 Lymphocyte Count,
CD4-Positive T-Lymphocytes,
HIV Infections,
Maternal-Child Health Centers,
Pregnancy Complications, Infectious,
Prenatal Diagnosis,
Rural Health Services,
Retrospective Studies,
Syphilis/diagnosis,
Syphilis Serodiagnosis,
Mozambique
Background: An observational study was conducted in Maputo, Mozambique, to investigate trends in prevalence of HIV drug resistance (HIVDR) in antiretroviral (ART) naïve subjects initiating highly active antiretroviral treatment (HAART).
Methodology/principal findings: To evaluate the pattern of drug res...
Ambulatory Care,
Antiretroviral Therapy, Highly Active,
CD4 Lymphocyte Count,
Drug Resistance, Viral,
HIV Infections/epidemiology,
HIV-1/drug effects,
Host-Pathogen Interactions,
Mutation,
Prevalence,
Treatment Failure,
Viral Load/radiation effects,
Anti-Retroviral Agents/therapeutic use,
Drug Resistance, Viral/genetics,
Genotype,
HIV Infections/rehabilitation,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/physiology,
Viral Load/genetics
