Carlucci, james;
Schacht, caroline de;
Graves, erin;
González, purificación;
Bravo, magdalena;
Yu , zhihong;
Amorim , gustavo;
Arinze, folasade;
Silva, wilson;
Tique, jose a;
Alvim, maria;
Simione, beatriz;
Fernando, anibal n;
Wester, c william.
Background: Historically, antiretroviral therapy (ART) initiation was based on CD4 criteria, but this has been replaced with "Test and Start" wherein all people living with HIV are offered ART. We describe the baseline immunologic status among children relative to evolving ART policies in Mozambique.
Me...
Background: There has been tremendous progress in the fight against HIV worldwide; however, challenges persist in the control of HIV infection. These challenges include the high prevalence of late presenters. There are many disadvantages of late presentation-from reduced survival of the infected person t...
Lamp, Katherine;
McGovern , Seth;
Fong, Youyi;
Atem, Charles Diko;
Nfetam, Jean Bosco Elat;
Nzuobontane 3, Divine;
Bollinger, Timothy;
Jani 6, Ilesh;
Sitoe, Nadia;
Kiyaga 7, Charles;
Senyama, George;
Mangwendeza, Phibeon M;
Zinyowera, Sekesai Mtapuri;
Doi, Naoko;
Peter, Trevor;
Sacks, Jilian A;
Vojnov, Lara.
Background: Globally, nearly 22 million HIV-infected patients are currently accessing antiretroviral treatment; however, almost one million people living with HIV died of AIDS-related illnesses in 2018. Advanced HIV disease remains a significant issue to curb HIV-related mortality.
Methods: We analyzed 8...
Uganda,
Primary Health Care,
Humans,
HIV Infections,
Data Collection,
Cameroon,
CD4 Lymphocyte Count,
Ambulatory Care Facilities,
Africa South of the Sahara/epidemiology,
Epidemiology,
Mozambique/epidemiology
Fernández-Luis, Sheila;
Nhampossa, Tacilta;
Fuente-Soro, Laura;
Augusto, Orvalho;
Casellas, Aina;
Bernardo, Edson;
Ruperez, Maria;
Gonzalez, Raquel;
Maculuve, Sonia;
Saura-Lázaro, Anna;
Menendez, Clara;
Naniche, Denise;
Lopez-Varela, Elisa.
Background: There are 170,000 children living with HIV in 2017 in Mozambique. Scaling-up HIV care requires effective retention along the cascade. We sought to evaluate the pediatric cascade in HIV care at the Manhiça District Hospital. Methods: A prospective cohort of children <15 years was followed fro...
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
AIDS Vaccines/immunology,
Antibodies, Neutralizing/immunology,
CD4 Lymphocyte Count,
Cytokines/biosynthesis,
HIV Antibodies/immunology,
HIV Infections/prevention & control,
HIV Infections/virology,
HIV-1/immunology,
HIV-1/genetics,
Mozambique,
CD8-Positive T-Lymphocytes/immunology,
T-Lymphocytes, Regulatory/metabolism,
Vaccines, DNA/immunology,
Vaccines, DNA/genetics
Retention in anti-retroviral therapy (ART) presents a challenge in sub-Saharan Africa. In
Mozambique, after roll-out to peripheral facilities, the 12-month retention rate was reported
mostly from sites with an electronic patient tracking system (EPTS), representing only 65%
of patients. We conducted a na...
Anti-HIV Agents/pharmacology,
CD4 Lymphocyte Count,
Death,
Lost to Follow-Up,
Patient Identification Systems,
HIV,
Adolescent,
Mozambique/epidemiology,
HIV Testing,
Anti-Retroviral Agents/therapeutic use,
HIV/drug effects,
Pregnancy
Marotta, Claudia;
Giaquinto, Carlo;
i Gennaro, Francesco;
Chhaganlal, Kajal D;
Saracino, Annalisa;
Moiane, Jorge;
aringhini, Guido;
Pizzol, Damiano;
Putoto, Giovanni;
Monno, Laura;
Casuccio, Alessandra;
Vitale, Francesco;
Mazzucco, Walter.
Background: In 2013, Mozambique implemented task-shifting (TS) from clinical officers to maternal and child
nurses to improve care for HIV positive children < 5 years old. A retrospective, pre-post intervention study was
designed to evaluate effectiveness of a new pathway of care in a sample of Beira Dis...
Rupérez, María;
Julian, Marc Noguera;
González, Raquel;
Maculuve, Sonia;
Bellido, Rocío;
Vala, Anifa;
Rodríguez, Cristina;
Sevene, Esperança;
Paredes, Roger;
Menéndez, Clara.
Background: Few data on HIV resistance in pregnancy are available from Mozambique, one of the countries with the highest HIV toll worldwide. Understanding the patterns of HIV drug resistance in pregnant women might help in tailoring optimal regimens for prevention of mother to child transmission of HIV (...
Anti-HIV Agents/administration & dosage,
CD4 Lymphocyte Count/methods,
Drug Resistance, Viral,
HIV Infections/drug therapy,
Drug Resistance, Viral/drug effects,
Infectious Disease Transmission, Vertical/prevention & control,
Pregnancy Complications, Infectious/drug therapy,
Mozambique,
Prenatal Care/methods,
HIV-1/chemistry
Auld, Andrew F;
Shiraishi, Ray W;
Oboho, Ikwo;
Ross, Christine;
Bateganya, Moses;
Pelletier, Valerie;
Francois, Kesner;
Delcher, Chris;
Desforges, Gracia;
Griswold, Mark;
Domercant, Jean Wysler;
Joseph, Nadjy;
Deyde, Varough;
Desir, Yrvel;
Chun, Helen;
Zulu, Isaac;
Pathmanathan, Ishani;
Robin, Ermane;
Gudo, Eduardo Samo.
Monitoring prevalence of advanced human immunodeficiency virus (HIV) disease (i.e., CD4+ T-cell count <200 cells/μL) among persons starting antiretroviral therapy (ART) is important to understand ART program outcomes, inform HIV prevention strategy, and forecast need for adjunctive therapies.*,†,§ To...
A contagem dos Linfócitos TCD4+ no sangue periférico continua a ser um importante marcador para monitorar a progressão da doença e eficácia da terapia anti-retroviral (ART), apesar da introdução recentemente da testagem de carga viral, por ser um indicador mais sensível que a contagem de CD4; e c...
