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Effect of seven anti-tuberculosis treatment regimens on sputum microbiome: a retrospective analysis of the HIGHRIF study 2 and PanACEA MAMS-TB clinical trials

Musisi, Emmanuel; Wyness, Adam; Eldirdiri, Sahar; Dombay, Evelin; Mtafya, Bariki; Ntinginya, Nyanda E; Heinrich, Norbert; Kibiki, Gibson S; Hoelscher, Michael; Boeree, Martin; Aarnoutse, Rob; Gillespie, Stephen H; Sabiiti, Wilber.
The Lancet microbe; 4 (11), 2023
Background: Respiratory tract microbiota has been described as the gatekeeper for respiratory health. We aimed to assess the impact of standard-of-care and experimental anti-tuberculosis treatment regimens on the respiratory microbiome and implications for treatment outcomes. Methods: In this retrospect...
d0060900, d0121890, d0057960, d0091610, d0087220, d0149440, d0062620, Tuberculosis/diagnosis, Communicable Diseases/drug therapy, Respiratory Tract Diseases/prevention & control
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Plano estrategico Multissectorial de prevenção e controlo de doenças não transmissíveis
Multisectoral strategic plan for the prevention and control of non-communicable diseases

Marlene, rosa; Tiago, armindo daniel; Fernandes, aires.
A morte prematura por Doenças Não Transmissíveis (DNTs), continua a ser um dos principais desafios para o desenvolvimento a nível global, ceifando por ano perto de 15 milhões de vidas em idades compreendidas entre 30 e 70 anos. Moçambique não permanece inócuo pois já é notável a transição ep...
Communicable Diseases/epidemiology, Noncommunicable Diseases, Communicable Diseases/drug therapy, Mortality, Premature/trends, Nicotiana, Communicable Disease Control/methods, Diet, Food, and Nutrition, Chancre/prevention & control, Cervix Uteri/growth & development, HIV/growth & development, Mozambique
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Incidence of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome and impact on patient outcome

Bonnet, Maryline; Baudin, Elisabeth; Jani, Ilesh V; Nunes, Elizabete; Verhoutraten, François; Calmy, Alexandra; Batos, Rui; Bhatt, Nilesh B; Michon, Christophe.
PLos ONE; 8 (12), 2013
We used data from a randomized trial of HIV-tuberculosis co-infected patients in Mozambique to determine the incidence and predictors of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) occurring within 12 weeks of starting antiretroviral therapy, and to evaluate its...
AIDS-Related Opportunistic Infections, Anti-Retroviral Agents, Immune Reconstitution Inflammatory Syndrome, Incidence, Mozambique/epidemiology, Tuberculosis/prevention & control, Epidemiology, Tuberculosis, Pulmonary/drug therapy, Communicable Diseases/drug therapy
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