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Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

Corey, lawrence; Gilbert, peter B; Juraska, michal; Montefiori, david C; Morris, lynn.
N. Engl. j. med; 384 (11), 2021
BACKGROUND—Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear. METHODS—We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the HVTN 704/HPTN 085 trial and at-risk women in sub-Sah...
Africa South of the Sahara, Antibodies, Monoclonal, Broadly Neutralizing Antibodies, Double-Blind Method, HIV Antibodies, HIV Infections, Mozambique
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Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial

González, Raquel; Desai, Meghna; Macete 3, Eusebio; Ouma, Peter; Kakolwa, Mwaka A; Abdulla, Salim; Aponte, John J; Bulo, Helder; Kabanywanyi, Abdunoor M; Katana, Abraham; Maculuve, Sonia; Mayor, Alfredo; Nhacolo, Arsenio; Otieno, Kephas; Pahlavan, Golbahar; Rupérez, María; Sevene, Esperança; Slutsker, Laurence; Vala, Anifa; Williamsom, John; Menéndez, Clara.
PloS med; 14 (160), 2014
Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women taking daily cotrimoxazole prophylaxis (CTXp) because of potential added risk of adve...
Antimalarials/administration & dosage, Double-Blind Method, Follow-Up Studies, HIV Infections/diagnosis, HIV Infections/drug therapy, HIV Infections/epidemiology, Infectious Disease Transmission, Vertical/prevention & control, Malaria/diagnosis, Malaria/epidemiology, Malaria/prevention & control, Mefloquine/administration & dosage, Pregnancy Complications, Infectious/diagnosis, Pregnancy Complications, Infectious/epidemiology, Pregnancy Complications, Infectious/prevention & control, Pregnancy Complications, Parasitic/diagnosis, Pregnancy Complications, Parasitic/epidemiology, Pregnancy Complications, Parasitic/prevention & control, Pregnancy Outcome, Mozambique/epidemiology, Tanzania/epidemiology, Kenya/epidemiology, Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage
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Safety of the RTS, S/AS02A malaria vaccine in Mozambican children during a Phase IIb trial
Safety of the RTS,S/AS02A malaria vaccine in Mozambican children during a Phase IIb trial

Sacarlal, Jahit; Aponte, John J; Aide, Pedro; Mandomando, Inácio; Bassat, Quique; Guinovart, Caterina; Leach, Amanda; Milman, Jessica; Macete, Eusebio; Espasa, Mateu; Ofori-Anyinam, Opokua; Thonnard, Joelle; Corachan, Sabine; Dubois, Marie-Claude; Lievens, Marc; Dubovsky, Filip; Ballou, W Ripley; Cohen, Joe; Alonso, Pedro L.
Vaccine; 26 (2), 2008
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Malaria Vaccines/adverse effects, Malaria, Falciparum/prevention & control, Mozambique/epidemiology, Child, Preschool, Double-Blind Method, Malaria Vaccines/administration & dosage, Malaria, Falciparum/immunology, Malaria, Falciparum/epidemiology
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