González, Raquel;
Nhampossa, Tacilta;
Mombo-Ngoma, Ghyslain;
Mischlinger, Johannes;
Esen, Meral;
Tchouatieu, André-Marie;
Mendes, Anete;
Figueroa-Romero, Antía;
Zoleko-Manego, Rella;
Lell, Bertrand;
Lagler, Heimo;
Stoeger, Linda;
Dimessa, Lia Betty;
El Gaaloul, Myriam;
Sanz, Sergi;
Méndez, Susana;
Piqueras, Mireia;
Sevene, Esperança;
Ramharter, Michael;
Saúte, Francisco;
Menendez, Clara.
For this randomised, double-blind, placebo-controlled clinical trial, women with HIV attending the first antenatal care clinic visit, resident in the study area, and with a gestational age up to 28 weeks were enrolled at five sites in Gabon and Mozambique. Participants were randomly assigned (1:1) to rec...
Antimalarials/administration & dosage,
Artemisinins/administration & dosage,
Double-Blind Method,
Drug Combinations,
Gabon,
HIV Infections/complications,
Malaria/therapy,
Malaria/prevention & control,
Piperazines,
Pregnancy Complications,
Quinolines/administration & dosage,
Treatment Outcome,
Trimethoprim, Sulfamethoxazole Drug Combination,
Antimalarials/therapeutic use,
Antimalarials/adverse effects,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Mozambique/epidemiology,
Pregnancy Complications, Infectious/therapy,
Pregnancy Complications, Infectious/prevention & control
Nhama , Abel;
Nhamússua, Lídia;
Macete, Eusébio;
Bassat, Quique;
Salvador, Crizolgo;
Enosse, Sónia;
Candrinho, Baltazar;
Carvalho, Eva;
Nhacolo, Arsénio;
Chidimatembue, Arlindo;
Saifodine , Abuchahama;
Zulliger, Rose;
Lucchi, Naomi;
Svigel, Samaly S;
Moriarty , Leah F;
Halsey, Eric S;
Mayor, Alfredo;
Aide , Pedro.
Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy...
Amodiaquine,
Antimalarials/therapeutic use,
Drug Combinations,
Antimalarials/standards,
Parasitemia,
Treatment Outcome,
d0082880,
Artemether, Lumefantrine Drug Combination/pharmacology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Malaria, Falciparum/therapy,
Parasitemia/drug therapy,
Mozambique/epidemiology
Huijben, silvie;
Macete, eusebio;
Ngoma, ghyslain mombo;
Ramharter, michael;
Kariuki, Simon;
Desai, meghna;
Shi, ya ping;
Uberegui, estefania;
Mwangoka, grace;
Massougbodji, achille;
Cot, michel;
Ndam, nicaise tuikue;
Gupta, himanshu;
Cisteró, pau;
Aponte, john, j;
González, raquel;
Menéndez, clara;
Mayor, alfredo.
Background: Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions.
Methods: Plasmod...
Antimalarials/therapeutic use,
Drug Combinations,
Drug Resistance, Multiple/drug effects,
Malaria, Falciparum/blood,
Mefloquine/therapeutic use,
Polymorphism, Genetic,
Malaria, Falciparum/drug therapy,
Malaria/epidemiology
Arnaldo, Paulo;
Vallbona, Eduard Rovira;
Langa, Jerónimo S;
Salvador, Crizolgo;
Guetens, Pieter;
Chiheb, Driss;
Xavier , Bernardete;
Kestens, Luc;
Enosse, Sónia M;
Urgell , Anna Rosanas.
Background: Malaria in pregnancy leads to serious adverse effects on the mother and the child and accounts for 75,000–200,000 infant deaths every year. Currently, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine–pyrimethamine (...
Pyrimethamine/administration & dosage,
Sulfadoxine/administration & dosage,
Antimalarials/therapeutic use,
d0090350,
Antimalarials/administration & dosage,
Pharmaceutical Preparations,
Surveys and Questionnaires/statistics & numerical data,
Drug Combinations,
Labor, Obstetric/radiation effects,
Pregnancy Complications, Parasitic,
Mozambique,
Malaria/prevention & control
Salvador, Crizolgo;
Rafael, Bernardete;
Matsinhe, Francisco;
Matsinhe, Francisco;
Candrinho , Baltazar;
Muthemba , Rosália;
Carvalho, Eva;
Naueia, Eva;
Sacarlal, Jahit;
Namboze, Josephine;
Tiago , Armindo;
Warsame, Marian;
Enosse, Sónia.
he resistance of Plasmodium falciparum to anti-malarial drugs continues to challenge malaria control. We assessed the therapeutic efficacy and safety of artemether-lumefantrine (AL), the first-line treatment of uncomplicated P. falciparum malaria, in children under five years of age in Mozambique. We con...
Antimalarials/therapeutic use,
Artemisinins/therapeutic use,
Malaria/epidemiology,
d0109630,
d0200660,
d0161330,
Artemether, Lumefantrine Drug Combination,
Drug Combinations,
Ethanolamines/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/genetics,
Polymerase Chain Reaction,
Mozambique/epidemiology
Rupérezm, María;
González, Raquel;
Ngoma, Ghyslain Mombo-;
Kabanywanyi, Abdunoor M;
Sevene, Esperança;
Ouédraogo, Smaïla;
Briand, Valérie;
Aponte, John J;
Zoleko, Rella Manego;
Adegnika, Ayôla A;
Cot, Michel;
Kremsner, Peter G;
Massougbodji, Achille;
Abdulla, Salim;
Ramharter, Michael;
Macete, Eusébio;
Menéndez, Clara.
Background: Little is known about the effects of intermittent preventive treatment of malaria in pregnancy (IPTp) on the health of sub-Saharan African infants. We have evaluated the safety of IPTp with mefloquine (MQ) compared to sulfadoxine-pyrimethamine (SP) for important infant health and developmenta...
Child Development/radiation effects,
Malaria/prevention & control,
Maternal Exposure/adverse effects,
Mefloquine/adverse effects,
Pregnancy Complications, Parasitic/prevention & control,
Prenatal Exposure Delayed Effects/epidemiology,
Antimalarials/therapeutic use,
Drug Combinations,
Prenatal Exposure Delayed Effects/chemically induced,
Survival Rate/trends,
Mozambique/ethnology
Baiden, Rita;
Oduro, Abraham;
Halidou, Tinto;
Gyapong, Margaret;
Sie, Ali;
Macete, Eusebio;
Abdulla, Salim;
Agyei, Seth Owusu;
Mulokozi, Abdunoor;
Adjei , Alex 10;
Sevene, Esperanca;
Compaore, Guillaume;
Valea, Innocent;
Osei, Isaac;
Yawson, Abena;
Adjuik, Martin;
Akparibo, Raymond;
Ogutu, Bernhards;
Upunda, Gabriel Leonard;
Smith, Peter;
Binka, Fred.
Background: The World Health Organization recommends artemisinin-based combination (ACT) for the treatment of uncomplicated malaria. Post-licensure safety data on newly registered ACT is critical for evaluating their risk/benefit profile in malaria endemic countries. The clinical safety of the newly regi...
Nhama, Abel;
Bassat 1, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunateamodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentre...
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Artesunate/therapeutic use,
Fluorenes/therapeutic use,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Artemether, Lumefantrine Drug Combination/therapeutic use,
Mozambique/epidemiology
Nhama, Abel;
Bassat, Quique;
Enosse, Sónia;
Nhacolo, Arsenio;
Mutemba, Rosália;
Carvalho, Eva;
Naueia, Eva;
Sevene, Esperança;
Guinovart, Caterina;
Warsame, Marian;
Sanz, Sergi;
Mussa, Abdul;
Matsinhe, Graça;
Alonso, Pedro;
Tiago, Armindo;
Macete, Eusebio.
Background: Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentr...
Amodiaquine/adverse effects,
Amodiaquine/therapeutic use,
Antimalarials/adverse effects,
Antimalarials/therapeutic use,
Artemether, Lumefantrine Drug Combination,
Artemisinins/adverse effects,
Artemisinins/therapeutic use,
Drug Combinations,
Ethanolamines/adverse effects,
Ethanolamines/therapeutic use,
Fluorenes/adverse effects,
Fluorenes/therapeutic use,
Kaplan-Meier Estimate,
Malaria, Falciparum/drug therapy,
Malaria, Falciparum/epidemiology,
Treatment Outcome,
Mozambique/epidemiology
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pyrimethamine/pharmacology,
Protozoan Proteins/genetics,
Malaria, Falciparum/epidemiology,
d0161330,
d0138120,
Mozambique/epidemiology,
Ligases,
Drug Combinations,
Drug Resistance/genetics,
Ezetimibe, Simvastatin Drug Combination/therapeutic use,
Pyrimethamine/supply & distribution,
Pharmaceutical Preparations,
Haplotypes/genetics,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/isolation & purification,
Protozoan Proteins/standards,
Sulfadoxine/pharmacology
