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Mapping Antimalarial Drug Resistance in Mozambique: A Systematic Review of Plasmodium falciparum Genetic Markers Post-ACT Implementation

Chaves, Celso Raul Silambo; Silva, Clemente da; Salamandane, Acácio; Nogueira, Fatima.
Int. j. mol. sci. (Online); 25 (24), 2024
Abstract Malaria continues to be a significant public health burden in many tropical and subtropical regions. Mozambique ranks among the top countries affected by malaria, where it is a leading cause of morbidity and mortality, accounting for 29% of all hospital deaths in the general population and 42% o...
Antimalarials/pharmacology, Patients, Morbidity, Pregnant Women, Genes, Malaria, Plasmodium falciparum, Drug Resistance
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Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population

Arnaldo, Paulo; Thompson, Ricardo Estevão; Lopes, Márcia Quinhones; Suffys, Philip Noe; Santos, Adalberto Rezende.
Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Po; 20(4) (), 2012
Background: The cytochrome P450 enzymes (CYP) play an important role in the metabolism of many therapeutic agents. The activities of different enzymes exhibit variability in different populations, which causes variations in drug response or toxicity. The CYP2B6 and CYP2C8 enzymes are encoded by polymorph...
Isoenzymes, Cytochrome P-450 Enzyme System, d0657020, Cytochrome P-450 CYP2C8, Polymorphism, Single Nucleotide, Polymorphism, Restriction Fragment Length, Enzymes, Therapeutics, Antimalarials, Blood Donors, Genes
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