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Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations

Bezerra, Ohanna Cavalcanti de Lima; Arnez, Lucia Elena Alvarado; Mabunda, Nedio; Salomé, Graça; Sousa, Amina de; Kehdy, Fernanda de Souza Gomes; Marques, Carolinne Sales; Manta, Fernanda Saloum de Neves; Andrade, Rafaela Mota; Ferreira, Lais Pereira; Calvo, Thyago Leal; Cardoso, Cynthia Chester; Nunes, Kelly; Gouveia, Matheus H; Mbulaiteve, Sam M; Yeboah, Edward D; Hsing, Ann; Latini, Ana Carla Pereira; Leturiondo, André Luiz; Rodrigues, Fabiola da Costa; Noronha, Ariani Batista; Ferreira, Cinthia de Oliveira; Talhari, Carolina; Rêgo, Jamile Leão; Castellucci, Léa Cristina de Carvalho; Terazona-Santos, Eduardo; Carvalho, Elizeu Fagundes de; Meyer, Diogo; Pinheiro, Roberta Olmo; Jani, Ilesh V; Pacheco, Antonio Guilherme; Moraes, Milton Ozório.
PLoS Negl Trop Dis; 15 (8), 2021
Investigation of human genes under pathogen-driven selection as Plasmodium sp. has pinpointed genetic variants that participate in the adaptation to the environment and/or are related to severities of human diseases. The current study examined an example of an evolutionary trade-off in which genetic vari...
Malaria/genetics, Polymorphism, Single Nucleotide, Pyruvate Kinase/genetics, Mozambique, Brazil, Genetic Predisposition to Disease, Haplotypes, Gene Frequency, d0111530
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