Strydom, Amy;
Donato, celeste m;
Nyaga, martin m;
Boene, simone s;
Peenze, Ina;
Mogotsi, Milton T;
João, Eva D;
Munlela, benilde;
Potgieter, A. Christiaan;
Seheri, mapaseka L;
de Deus, Nilsa;
O’Neill, hester G.
This study presents whole genomes of seven bovine rotavirus strains from South Africa and Mozambique. Double-stranded RNA, extracted from stool samples without prior adaptation to cell culture, was used to synthesise cDNA using a self-annealing anchor primer ligated to dsRNA and random hexamers. The cDNA...
A doença diarreica na infância constitui um importante problema de saúde
pública em Moçambique. A infecção pelo Rotavirus é a uma das causas mais comum de diarreia
aguda grave a nível mundial, sendo a diarreia terceira causa de morbi-mortalidade infantil na
maioria d...
Child,
Diarrhea,
Disease,
Genotype,
Infections,
Rotavirus Infections,
Pediatrics,
Rotavirus,
Health,
Hospitals, General
Joao, eva dora;
Stroydon, amey;
Oneil g, hester;
Cumba, assa;
Cossecera, marta;
Acacio, sozinho;
Mandomando, inácio;
Motanyane, lithabiso;
Page, nicola;
Deus, nilsa de.
In Mozambique rotavirus (RV) was shown to be the greatest cause of acute diarrhoea in infants from 0 to 11 months, and in 2015, national rotavirus vaccination was introduced. As with other developing countries, there is very limited active strain characterisation. Rotavirus positive clinical specimens, c...
Gastroenteritis/virology,
Genotype,
Rotavirus Infections/virology,
Acute Disease,
Phylogeny,
Rotavirus/genetics,
Antigens, Viral/genetics,
Genetic Variation,
Gene Expression Regulation, Viral,
Mozambique,
Epitopes/genetics
Jordan, M Michael;
Penazzato, Martina;
Cournil, Amandine;
Vubil, Adolfo;
Jani, Ilesh;
Hunt, Gilian;
Maphalala, Gudo;
Carmona, Sergio;
Mthethwa, Nobuhle;
Watera, Christine;
Kaleebu, Pontiano;
Musanhu, Christine Chaknyuka;
Mtapuri-Zinyowera, Sekasai;
Dzangare, Janet;
Peeters, Martine;
Yang, Chunfu;
Parkin, Iveil;
Bertagnolio, Silvia.
Background. Programs for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) have been scaled up in many low- and middle-income countries. However, HIV drug resistance (HIVDR) data among HIV-1– infected young children remain limited.
Methods. Surveys of pretreat...
A tuberculose (TB) é uma doença infecciosa que ameaça a humanidade há séculos. Recentemente grandes
avanços foram conseguidos no combate à tuberculose, entretanto a resistência bacilar e a coinfecção pelo
Vírus de Imunodeficiência Humana (HIV) persistem como os principais desafios dos program...
Drug Resistance, Bacterial,
Mycobacterium tuberculosis/drug effects,
Genotype,
Antibiotics, Antitubercular/pharmacology,
Coinfection,
Tuberculosis, Multidrug-Resistant/microbiology,
Prevalence,
Tuberculosis/microbiology,
Microbial Sensitivity Tests,
Mycobacterium tuberculosis/genetics,
HIV Infections/epidemiology,
Mozambique/epidemiology
Rupérez, María;
Pou, Christian;
Maculuve, Sonia;
Cedeño, Samandy;
Luis, Leopoldina;
Rodríguez, Judith;
Letang, Emilio;
Moltó, José;
Macete, Eusébio;
Clotet, Boaventura;
Alonso, Pedro;
Menéndez, Clara;
Naniche, Denise;
Paredes, Roger.
Objectives: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique.
Methods: This was a cross-sectional study. HIV-1-infected adults on first-line ART for at least 1 year attending routine visits in the Manhiça District Hospi...
Anti-Retroviral Agents/therapeutic use,
Drug Monitoring,
Drug Resistance, Viral,
Genotype,
Genotyping Techniques,
HIV Infections/drug therapy,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/isolation & purification,
Suburban Population,
Treatment Failure,
Mozambique,
Drug Resistance
Background: An observational study was conducted in Maputo, Mozambique, to investigate trends in prevalence of HIV drug resistance (HIVDR) in antiretroviral (ART) naïve subjects initiating highly active antiretroviral treatment (HAART).
Methodology/principal findings: To evaluate the pattern of drug res...
Ambulatory Care,
Antiretroviral Therapy, Highly Active,
CD4 Lymphocyte Count,
Drug Resistance, Viral,
HIV Infections/epidemiology,
HIV-1/drug effects,
Host-Pathogen Interactions,
Mutation,
Prevalence,
Treatment Failure,
Viral Load/radiation effects,
Anti-Retroviral Agents/therapeutic use,
Drug Resistance, Viral/genetics,
Genotype,
HIV Infections/rehabilitation,
HIV Infections/virology,
HIV-1/genetics,
HIV-1/physiology,
Viral Load/genetics
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...
HIV-1/genetics,
Amino Acid Sequence,
Anti-HIV Agents,
Cluster Analysis,
Drug Resistance, Viral,
Enfuvirtide,
Genotype,
HIV Envelope Protein gp41/genetics,
HIV Infections/virology,
HIV-1/classification,
Molecular Sequence Data,
Mozambique,
Mutation, Missense,
Peptide Fragments,
Phylogeny,
Polymorphism, Genetic,
RNA, Viral,
Sequence Alignment,
Sequence Analysis, DNA,
Treatment Failure
Enfuvirtide was the first fusion inhibitor approved by the Food and Drug Administration (FDA) in 2003 for HIV-1 infection in treatment-experienced patient. It is the first approved antiviral agent to attack the HIV life cycle in its early stages. For HIV fusion to occur, the HR1 and HR2 domains in the gp...
Mozambique,
Infections,
HIV-1/growth & development,
Circumcision, Male,
Molecular Sequence Data,
Polymorphism, Genetic,
Treatment Failure,
Sequence Analysis, DNA,
Genotype,
Drug Resistance, Viral,
HIV Infections
Multiple-locus variable-number tandem repeat analysis (MLVA) is useful to establish transmission routes and sources of infections for various microorganisms including Mycobacterium tuberculosis complex (MTC). The recently released SITVITWEB database contains 12-loci Mycobacterial Interspersed Repetitive ...
Bacterial Typing Techniques,
Bayes Theorem,
Genetic Loci/genetics,
Genotype,
Internationality,
Interspersed Repetitive Sequences/genetics,
Microsatellite Repeats/genetics,
Mycobacterium tuberculosis/classification,
Mycobacterium tuberculosis/genetics,
Phylogeny,
Phylogeography
