Gray, Glenda E;
Mngadi, Kathryn;
Lavreys, Ludo;
Nijs, Steven;
Gilbert, Peter B;
Hural, John;
Hyrien, Ollivier;
Juraska, Michal;
Luedtke, Alex;
Mann, Philipp;
McElrath, M Juliana;
Odhiambo, Jackline A;
Stieh, Daniel J;
Duijn, Janine van;
Takalani, Azwidihwi N;
Willems, Wouter;
Tapley, Asa;
Tomaras, Georgia D;
Hoof, Johan Van;
Schuitemaker, Hanneke;
Swann, Edith;
Barouch, Dan H;
Kublin, James G;
Corey, Lawrence;
Pau, Maria G;
Buchbinder, Susan;
Tomaka, Frank.
Background: HIV type 1 (HIV-1) remains a global health concern, with the greatest burden in sub-Saharan Africa. Despite 40 years of research, no vaccine candidate has shown durable and protective efficacy against HIV-1 acquisition. Although pre-exposure prophylaxis in groups with high vulnerability can b...
BACKGROUND—Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear. METHODS—We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the HVTN 704/HPTN 085 trial and at-risk women in sub-Sah...
Augusto, Ângelo do Rosário;
Nnaemeka, Nnaemeka C;
Kohatsu, Luciana;
Sousa, Leonardo de;
Maueia, Cremildo;
Hara, Cristina;
Mula, Flora;
Cuamba, Gércio;
Chelene, Imelda;
Langa, Zainabo;
Lohman, Nathaniel;
Faife, Flávio;
Giles, Denise;
Sabonete, Acácio José;
Gudo, Eduardo Samo;
Jani, Ilesh;
Parekh, Bharat S.
Effective implementation of the national Human Immunodeficiency Virus (HIV) programs require monitoring the HIV epidemic trends to identify programmatic successes, challenges, and needed improvements. HIV prevalence estimates, defined as the percentage of a population affected by HIV, are calculated by t...
A Tuberculose Latente (TBL) é definida como um estado de resposta imunológica persistente à estimulação pelo antígeno do Mycobacterium tuberculosis sem evidência de manifestação clínica da doença activa.
A probabilidade de progressão da infecção para doença activa depende de vários factor...
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
AIDS Vaccines/immunology,
Antibodies, Neutralizing/immunology,
CD4 Lymphocyte Count,
Cytokines/biosynthesis,
HIV Antibodies/immunology,
HIV Infections/prevention & control,
HIV Infections/virology,
HIV-1/immunology,
HIV-1/genetics,
Mozambique,
CD8-Positive T-Lymphocytes/immunology,
T-Lymphocytes, Regulatory/metabolism,
Vaccines, DNA/immunology,
Vaccines, DNA/genetics
Viegas, Edna Omar;
Tembe, Nelson;
Nilsson, Charlotta;
Meggi, Bindiya;
Maueia, Cremildo;
Augusto, Orvalho;
Stout, Richard;
Scarlatti, Gabriella;
Ferrari, Guido;
Earl, Patricia L;
Wahren, Britta;
Andersson, Soren.
According to UNAIDS, there were a total of 36.7 million people living with HIV and 2.1 million new infections in 2015. Eastern and Southern Africa continues to be most severely affected, accounting for 51.7% of the total global infections. Antiretroviral therapy has contributed to slowing the HIV epidemi...
HIV Antibodies,
Enzyme-Linked Immunospot Assay,
Injections, Intramuscular,
env Gene Products, Human Immunodeficiency Virus/immunology,
Mozambique,
Leukocytes, Mononuclear/immunology,
Vaccines, DNA/immunology,
AIDS Vaccines/immunology,
AIDS Vaccines/administration & dosage,
Immunization
Voronin, yegor;
Jani, ilesh;
Graham, barney, s;
Cunningham, coleen, k;
Mofenson, lynne, m;
Musoke, philippa, m;
Permar, sallie, r;
Scarlatti, gabriella.
Globally, 150,000 new paediatric human immunodeficiency virus type 1 (HIV-1) infections occurred in 2015. There remain complex challenges to the global elimination of paediatric HIV-1 infection. Thus, for the global community to achieve elimination of new paediatric HIV-1 infections, innovative approache...
HIV-1,
HIV-1/immunology,
AIDS Vaccines/administration & dosage,
HIV Antibodies,
AIDS Vaccines/immunology,
HIV Infections,
Antibodies, Neutralizing/immunology,
HIV Antibodies/immunology,
HIV Infections/immunology,
HIV Infections/prevention & control,
Infections/virology,
Infectious Disease Transmission, Vertical/prevention & control
Maueia, Cremildo;
Costa, Deise;
Meggi, Bindiya;
Ismael, Nalia;
Walle, Carla;
Curvo, Raphael;
Abreu, Celina;
Bhatt, Nilesh;
Tanuri, Amilcar;
Jani, Ilesh V;
Ferreira, Orlando C.
The HIV/AIDS pandemic is primarily caused by HIV-1. Another virus type, HIV-2, is found mainly in West African countries. We hypothesized that population migration and mobility in Africa may have facilitated the introduction and spreading of HIV-2 in Mozambique. The presence of HIV-2 has important implic...
Cross-Sectional Studies,
HIV Envelope Protein gp41,
HIV Antibodies,
Enzyme-Linked Immunosorbent Assay,
HIV Infections,
HIV-2,
Immunoblotting,
Incidence,
Mozambique,
Phylogeography,
Population Surveillance,
Viral Load
